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肝细胞癌中细胞因子信号传导抑制因子1与调节性T淋巴细胞/辅助性T淋巴细胞17平衡的关系

宋瑞 李静 杨红菊 李敏玥 游晶

引用本文:
Citation:

肝细胞癌中细胞因子信号传导抑制因子1与调节性T淋巴细胞/辅助性T淋巴细胞17平衡的关系

DOI: 10.3969/j.issn.1001-5256.2022.11.038
基金项目: 

国家自然科学基金 81760111;

国家自然科学基金 81760617;

国家卫生健康委员会毒品依赖和戒治重点实验室科学研究A类重点项目 2020DAMARA-003

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:宋瑞负责文献阅读及综述撰写;李静、杨红菊、李敏玥负责提供意见;游晶负责课题设计,拟定写作思路,指导撰写、修改文章并最后定稿。
详细信息
    通信作者:

    游晶,jingyoukm@126.com

Role of signal transducer and activator of transcription 1 in regulation of Treg/Th17 balance in hepatocellular carcinoma

Research funding: 

National Natural Science Foundation of China 81760111;

National Natural Science Foundation of China 81760617;

The NHC Key Laboratory of Drug Addiction Medicine Science Research A Key Project 2020DAMARA-003

More Information
  • 摘要: 调节性T淋巴细胞(Treg)和辅助性T淋巴细胞17(Th17)在肝细胞癌(HCC)的肿瘤微环境中发挥重要作用,Treg/Th17失衡与HCC的侵袭和进展密切相关。同时,细胞因子信号传导抑制因子1(SOCS1)作为Janus激酶/信号转导和转录激活因子信号通路的负调控因子之一,参与调控Treg细胞和Th17细胞的增殖、分化。本文主要分析HCC中SOCS1与Treg/Th17平衡的关系,探究HCC发生发展过程中的免疫相关机制。

     

  • 图  1  在HCC中SOCS1与Treg/Th17平衡的关系

    Figure  1.  The relationship between SOCS1 and Treg/Th17 balance in HCC

    图  2  SOCS1通过调控Foxp3的表达维持Treg功能的稳定[20]

    注:“→”表示促进,“ ”表示抑制。

    Figure  2.  SOCS1 maintains the stability of Treg function by regulating Foxp3 expression[20]

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  • 收稿日期:  2022-03-13
  • 录用日期:  2022-05-26
  • 出版日期:  2022-11-20
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