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骨髓间充质干细胞及其外泌体治疗终末期肝病的研究进展

梁悦 胡永红 刘伟 慕永平 陈佳美 刘平

引用本文:
Citation:

骨髓间充质干细胞及其外泌体治疗终末期肝病的研究进展

DOI: 10.3969/j.issn.1001-5256.2022.11.041
基金项目: 

国家自然科学基金重点项目 82130120;

国家自然科学基金面上项目 81973613;

中国博士后基金面上项目 2021M702218

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:梁悦负责收集、分析资料,撰写论文;胡永红、刘伟、慕永平参与收集文献,修改论文;陈佳美负责拟定文章框架,指导撰写文章并修改稿件;刘平负责拟定文章思路,指导撰写文章并修改稿件,最后定稿。
详细信息
    通信作者:

    陈佳美, cjm0102@126.com

    刘平, liuliver@vip.sina.com

Research advances in bone marrow mesenchymal stem cells and its exosomes in treatment of end-stage liver disease

Research funding: 

Key Project of National Natural Science Foundation of China 82130120;

General Project of National Natural Science Foundation of China 81973613;

China Postdoctoral Science Foundation 2021M702218

More Information
  • 摘要: 终末期肝病是各种急慢性肝病的晚期阶段,病死率高,严重危害人民健康。目前有效的治疗方法是肝移植,但囿于供体短缺、费用高昂等因素极大地限制了其临床应用。近年来临床与基础研究表明,骨髓间充质干细胞及其外泌体在治疗终末期肝病上具有良好的临床应用前景。本文就骨髓间充质干细胞及其外泌体在终末期肝病治疗中的作用机制与临床应用研究概况作一综述,期冀为进一步研究提供参考。

     

  • 图  1  BMSC及其外泌体治疗ESLD的作用机制

    Figure  1.  Mechanisms of BMSC and their exosomes in the treatment of end-stage liver diseases

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