中国丁型肝炎的研究发展史

刘慧敏; 毛青

doi:10.3969/j.issn.1001-5256.2023.04.002

中国丁型肝炎的研究发展史

DOI: 10.3969/j.issn.1001-5256.2023.04.002

刘慧敏,
毛青^, ,

陆军军医大学西南医院全军感染病研究所，重庆市感染病研究重点实验室，重庆 400038

详细信息

通信作者:
毛青，qingmao@tmmu.edu.cn (ORCID: 0000-0003-3138-2104)

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出版历程
- 收稿日期: 2023-02-15
- 录用日期: 2023-03-16
- 出版日期: 2023-04-20

Research history of hepatitis D in China

Huimin LIU,
Qing MAO^{,
,}

Chongqing Key Laboratory of Infectious Disease Research, Institute of Infectious Diseases of PLA, Southwest Hospital, Army Medical University, Chongqing 400038, China

More Information

Corresponding author: MAO Qing, qingmao@tmmu.edu.cn (ORCID: 0000-0003-3138-2104)

摘要

摘要: 自二十世纪七十年代发现丁型肝炎病毒(HDV)伊始，中国学者即开始针对HDV及丁型肝炎进行了大量的研究。本文通过查询中国科技期刊各大数据平台及我国学者在国外PubMed数据库期刊发表的相关文献，从历史发展的视角，全面分析总结了我国有关HDV及丁型肝炎从基础到临床的研究历程和科学发现。历年来，我国学者从检测技术方法建立、感染动物模型构建、核酶功能及应用、临床诊断与表现等方面开展了广泛研究。四十年来的研究成果，为进一步研究HDV的病毒学特征、感染机制、免疫应答与损伤、丁型肝炎的临床病理变化和抗病毒治疗奠定了基础。
- 丁型肝炎 /
- δ肝炎病毒 /
- 中国
Abstract: Since the discovery of hepatitis D virus (HDV) in the 1970s, Chinese scholars have started to conduct extensive studies on HDV and hepatitis D (HD). By searching for related articles published on the platforms of Chinese scientific and technological journals and the journals in PubMed database by Chinese scholars, this article comprehensively analyzes and summarizes the advances and scientific findings in HDV and HD by Chinese scholars from basic to clinical research from the perspective of historical development. Over the past years, Chinese scholars have conducted extensive research on the establishment of detection techniques and methods, the construction of infected animal models, the function and application of ribozymes, and clinical diagnosis and manifestation. The research findings in the past 40 years have laid a foundation for further research on the virological characteristics, infection mechanism, and immune response and injury of HDV, the clinicopathological changes of HD, and related antiviral treatment.
- Hepatitis D /
- Hepatitis Delta Virus /
- China

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图 1 各数据库丁型肝炎相关文献发表情况

Figure 1. Publication of the literature related to hepatitis D in various databases

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参考文献(60)

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