HDV RNA检测的研究现状

高耀; 任锋; 段钟平

doi:10.3969/j.issn.1001-5256.2023.04.004

HDV RNA检测的研究现状

DOI: 10.3969/j.issn.1001-5256.2023.04.004

高耀^{1, 2},
任锋^{1, 2},
段钟平^1, , ,

1.
首都医科大学附属北京佑安医院，北京市肝衰竭与人工肝重点治疗研究重点实验室，北京 100069
2.
北京肝病研究所，北京 100069

基金项目:

国家自然科学基金项目 (81770611);

国家自然科学基金项目 (82002243);

北京自然科学基金和北京市教委联合资助重点项目 (KZ202010025035);

首都卫生发展科研专项重点攻关项目 (SF2020-1-1151);

北京市属医学科研院所公益发展改革试点项目 (Beijing Medical Research No. 2021-10);

北京市卫健委高层次公共卫生技术人才建设项目“学科带头人”专项资助 (Subject leaders-02-13);

北京市医院管理中心“登峰人才”专项资助 (DFL20221503);

首都医科大学科研培育基金资助项目 (PYZ22130)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：高耀负责撰写论文；任锋、段钟平负责拟定写作思路并最后定稿。

详细信息

通信作者:
段钟平，duan2517@163.com (ORCID: 0000-0002-8455-0426)

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- 文章访问数: 396
- HTML全文浏览量: 49
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- 被引次数: 0
出版历程
- 收稿日期: 2023-02-21
- 录用日期: 2023-03-21
- 出版日期: 2023-04-20

Current research status of hepatitis D virus RNA detection

Yao GAO^{1, 2},
Feng REN^{1, 2},
Zhongping DUAN^{1
, ,
,}

1.
Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
2.
Beijing Institute of Hepatology, Beijing 100069, China

Research funding:

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Projects of the Beijing Municipal Education Commission's Science and Technology Plan (KZ202010025035);

Special Key Research Project of Capital Health Development Scientific Research (SF2020-1-1151);

Pilot Project of Public Welfare Development and Reform of Beijing Municipal Medical Research Institutes (Beijing Medical Research No. 2021-10);

High-level Public Health Technical Personnel Construction Project (Subject leaders-02-13);

Talent Cultivation plan of "Climbing the peak" of Beijing Municipal Hospital Administration (DFL20221503);

Research and Cultivation Foundation of Capital Medical University (PYZ22130)

More Information

Corresponding author: DUAN Zhongping, duan2517@163.com (ORCID: 0000-0002-8455-0426)

摘要

摘要: HDV感染导致的丁型肝炎是最严重的肝炎类型。由于缺乏精准HDV RNA检测方法，HDV的流行率被严重低估。HDV RNA是诊断HDV感染的金标准，在HDV的诊断、筛查和指导治疗方面具有重要意义。但因HDV基因型多、二级结构牢固，导致HDV RNA检测困难。本文就HDV RNA诊断方法的进展进行综述，阐述了HDV RNA检测方法从定性到定量检测的进展，为了解HDV RNA检测重要意义以及促进HDV RNA检测新方法的研发提供新思路。
- δ肝炎病毒 /
- RNA /
- 诊断
Abstract: Hepatitis D caused by hepatitis D virus (HDV) infection is the most serious type of viral hepatitis. The prevalence rate of HDV has been seriously underestimated due to the lack of accurate HDV RNA detection methods. HDV RNA is the gold standard for the diagnosis of HDV infection and is of great significance in the diagnosis, screening, and treatment guidance of HDV. However, the multiple genotypes and strong secondary structure of HDV have led to great difficulties in HDV RNA detection. This article reviews the advances in HDV RNA detection methods and elaborates on the development from qualitative to quantitative detection methods, in order to provide new ideas for understanding the significance of HDV RNA detection and promoting the research and development of new HDV RNA detection methods.
- Hepatitis Delta Virus /
- RNA /
- Diagnosis

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