新疆地区丁型肝炎的流行概况

郑嵘炅; 鲁晓擘

doi:10.3969/j.issn.1001-5256.2023.04.005

新疆地区丁型肝炎的流行概况

DOI: 10.3969/j.issn.1001-5256.2023.04.005

郑嵘炅,
鲁晓擘^, ,

新疆医科大学第一附属医院感染病·肝病中心，新疆感染性疾病(病毒性肝炎)临床医学研究中心，乌鲁木齐 830000

基金项目:

国家自然科学基金 (82060115)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：郑嵘炅参与查询文献，撰写部分文章；鲁晓擘负责拟定写作思路，撰写文章并最后定稿。

详细信息

通信作者:
鲁晓擘，xjykdluxiaobo@126.com (ORCID: 0000-0001-5532-7551)

计量
- 文章访问数: 350
- HTML全文浏览量: 74
- PDF下载量: 76
- 被引次数: 0
出版历程
- 收稿日期: 2023-02-15
- 录用日期: 2023-03-15
- 出版日期: 2023-04-20

Epidemiological situation of hepatitis D in Xinjiang, China

Rongjiong ZHENG,
Xiaobo LU^{,
,}

Center for Infectious Diseases-Hepatology, Xinjiang Clinical Medical Research Center for Infectious Diseases (Viral Hepatitis), The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

Research funding:

National Natural Science Foundation of China (82060115)

More Information

Corresponding author: LU Xiaobo, xjykdluxiaobo@126.com (ORCID: 0000-0001-5532-7551)

摘要

摘要: 丁型肝炎是全球性的公共卫生问题，HDV感染率在不同地区中的差异较大，基因型也各不相同，慢性HBV感染者重叠感染HDV可加速疾病进展，但丁型肝炎在很大程度上并未被予以重视。新疆地区是乙型肝炎的高发区域，然而关于丁型肝炎的研究比较缺乏。本文讨论HDV感染在新疆地区的流行概况，对新疆地区HDV感染率、不同民族之间的HDV分子流行病学研究以及周边毗邻国家HDV的感染现状进行简要综述，旨在为新疆地区开展HDV分子流行病学研究和疾病防控提供参考。
- 丁型肝炎 /
- 流行病学 /
- 新疆维吾尔自治区
Abstract: Hepatitis D is a global public health issue, and the infection rate and genotype of HDV infection vary greatly across different regions. The overlapping infection of hepatitis D virus (HDV) in patients with chronic hepatitis B virus (HBV) infection can accelerate disease progression, but hepatitis D has not been taken seriously to a large extent. Xinjiang in China is an area with a high incidence rate of hepatitis B, but there is a lack of research on hepatitis D. This article discusses the prevalence of HDV infection in Xinjiang and briefly reviews the prevalence rate of HDV infection in Xinjiang, the molecular epidemiology of HDV among different ethnic groups, and the current status of HDV infection in neighboring countries, so as to provide a reference for the conduct of molecular epidemiological research on HDV and disease prevention and control in Xinjiang.
- Hepatitis D /
- Epidemiology /
- Xinjiang

HTML全文

参考文献(35)

[1]	RIZZETTO M, CANESE MG, ARICÒ S, et al. Immunofluorescence detection of new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and in serum of HBsAg carriers[J]. Gut, 1977, 18(12): 997-1003. DOI: 10.1136/gut.18.12.997.
[2]	CHEN LY, PANG XY, GOYAL H, et al. Hepatitis D: challenges in the estimation of true prevalence and laboratory diagnosis[J]. Gut Pathog, 2021, 13(1): 66. DOI: 10.1186/s13099-021-00462-0.
[3]	LEE AU, LEE C. Hepatitis D review: Challenges for the resource-poor setting[J]. Viruses, 2021, 13(10): 1912. DOI: 10.3390/v13101912.
[4]	CHEN HY, SHEN DT, JI DZ, et al. Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis[J]. Gut, 2019, 68(3): 512-521. DOI: 10.1136/gutjnl-2018-316601.
[5]	SHEN L, GU Y, SUN L, et al. Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China[J]. J Med Virol, 2012, 84(3): 445-449. DOI: 10.1002/jmv.23212.
[6]	MAI K, JIN ZH, XIONG SS, et al. Investigation of hepatitis δ in some areas of China[J]. Chin J Epidemiol, 1989, 10 (1): 21-23. 买凯, 金志宏, 熊诗松, 等. 我国部分地区δ型肝炎调查研究[J]. 中华流行病学杂志, 1989, 10 (1): 21-23.
[7]	ZHAN MY, TANG SH, MA H, et al. Epidemiological investigation of hepatitis D virus infection in 25 provinces, cities and autonomous regions of China[J]. Chin J Virol, 1991(S1): 93-99. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB1991S1023.htm 詹美云, 汤少华, 马虹, 等. 我国25省市自治区丁型肝炎病毒感染的流行病学调查研究[J]. 病毒学报, 1991(S1): 93-99. https://www.cnki.com.cn/Article/CJFDTOTAL-BDXB1991S1023.htm
[8]	ROGGENBACH I, CHI X, LEMPP FA, et al. HDV seroprevalence in HBsAg-positive patients in China occurs in hotspots and is not associated with HCV mono-infection[J]. Viruses, 2021, 13(9): 1799. DOI: 10.3390/v13091799.
[9]	WANG Y. Investigation of hepatitis D virus infection and study of its molecular characteristics in China[D]. Beijing: Chinese Center for Disease Control and Prevention, 2018. 王彦. 我国丁型肝炎病毒感染情况调查和病毒分子特性研究[D]. 北京: 中国疾病预防控制中心, 2018.
[10]	ZHAO QM, ZHOU YS, LIAN ZH, et al. Epidemiological survey of HDV infection in some areas of China[J]. China Public Health, 1996, 12(5): 197-198. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW605.004.htm 赵秋敏, 周育森, 连振华, 等. 我国部分地区人群中HDV感染的流行病学调查[J]. 中国公共卫生, 1996, 12(5): 197-198. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGGW605.004.htm
[11]	PEI ZB, TAN XC, ZHANG YH. Report of HBV and HDV co-infection in different nationalities in Xinjiang[J]. Med J Natl Defend Forces Northwest China, 2004, 25(3): 228-229. DOI: 10.3969/j.issn.1007-8622.2004.03.033. 裴占宝, 谭欣诚, 张宇红. 新疆不同民族HBV与HDV重叠感染报告[J]. 西北国防医学杂志, 2004, 25(3): 228-229. DOI: 10.3969/j.issn.1007-8622.2004.03.033.
[12]	ZHANG N, SHI YF, ZHAO XQ, et al. Investigation and analysis of HDV markers in HBV infected people of different nationalities in Xinjiang[J]. Chin J Clin Lab Sci, 2005, 23(1): 64. DOI: 10.3969/j.issn.1001-764X.2005.01.029. 张农, 石永峰, 赵晓琼, 等. 新疆地区不同民族HBV感染者中HDV标志物调查分析[J]. 临床检验杂志, 2005, 23(1): 64. DOI: 10.3969/j.issn.1001-764X.2005.01.029.
[13]	WANG YX, AMANTUER, ZHANG K, et al. Investigation of hepatitis virus infection in Kizilsu Kirgiz Autonomous Prefecture[J]. Xinjiang Med J, 2006, 36(3): 188-189. DOI: 10.3969/j.issn.1001-5183.2006.03.123. 汪咏新, 阿满吐尔, 张昆, 等. 克州地区各型肝炎病毒感染调查[J]. 新疆医学, 2006, 36(3): 188-189. DOI: 10.3969/j.issn.1001-5183.2006.03.123.
[14]	REHEMAYI ABD. Investigation of HBV infection associated with HDV infection in Han and Kazak nationalities in Ili Kazakh Autonomous Prefecture, Xinjiang[J]. J Xinjiang Med Univ, 2006, 29(4): 358. DOI: 10.3969/j.issn.1009-5551.2006.04.027. 热合玛依·阿布都. 新疆伊犁地区汉、哈族HBV感染伴发HDV感染情况的调查[J]. 新疆医科大学学报, 2006, 29(4): 358. DOI: 10.3969/j.issn.1009-5551.2006.04.027.
[15]	ZHU B, ZHU JL. Study on the overlapping infection pattern of hepatitis B and hepatitis D in Xinjiang Uygur and Han nationality[J]. Chin J Integr Trad West Med Dig, 2010, 18(4): 265-266. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201004016.htm 朱兵, 朱江丽. 新疆维吾尔族和汉族乙型与丁型肝炎重叠感染模式的研究[J]. 中国中西医结合消化杂志, 2010, 18(4): 265-266. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXPW201004016.htm
[16]	ZHANG LJ, ZHENG RJ, ZHANG YX. Detection of hepatitis D virus markers in 380 patients with chronic hepatitis B[C]//Proceedings of the 13th National Conference on Infectious Diseases of the Chinese Medical Association, 2014. 张丽娟, 郑嵘炅, 张跃新. 380例慢乙肝患者血清中丁肝病毒标志物的检测[C]//中华医学会第十三次全国感染病学术会议论文汇编, 2014.
[17]	ZHENG RJ, TANGNUER TLF, DENG ZR, et al. Sero-epidemiological characteristics of the hepatitis D virus infection among hepatitis B virus infected-patients at a single center in Xinjiang region[J]. Chin J Hepatol, 2022, 30(10): 1044-1049. DOI: 10.3760/cma.j.cn501113-20220406-00169. 郑嵘炅, 唐努尔·塔拉甫, 邓泽润, 等. 新疆地区单中心乙型肝炎病毒感染者中丁型肝炎病毒感染的血清流行病学特点[J]. 中华肝脏病杂志, 2022, 30(10): 1044-1049. DOI: 10.3760/cma.j.cn501113-20220406-00169.
[18]	DONG Z, LI XM, ZHAO ZX. Progress in researches on molecular epidemiology of hepatitis B virus in various racial/ethnic populations[J]. China Public Health, 2020, 36(4): 650-653. DOI: 10.11847/zgggws1122201. 董哲, 李雪梅, 赵智娴, 等. 不同种族/民族乙型肝炎分子流行病学研究进展[J]. 中国公共卫生, 2020, 36(4): 650-653. DOI: 10.11847/zgggws1122201.
[19]	STOCKDALE AJ, KREUELS B, HENRION M, et al. The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis[J]. J Hepatol, 2020, 73(3): 523-532. DOI: 10.1016/j.jhep.2020.04.008.
[20]	BURM R, van HOUTTE F, VERHOYE L, et al. A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection[J]. JHEP Rep, 2023, 5(3): 100646. DOI: 10.1016/j.jhepr.2022.100646.
[21]	LIANG X, BI S, YANG W, et al. Epidemiological serosurvey of hepatitis B in China—declining HBV prevalence due to hepatitis B vaccination[J]. Vaccine, 2009, 27(47): 6550-6557. DOI: 10.1016/j.vaccine.2009.08.048.
[22]	ALFAIATE D, CLÉMENT S, GOMES D, et al. Chronic hepatitis D and hepatocellular carcinoma: A systematic review and meta-analysis of observational studies[J]. J Hepatol, 2020, 73(3): 533-539. DOI: 10.1016/j.jhep.2020.02.030.
[23]	DAMBADARJAA D, MUKHTAR Y, TSOGZOLBAATAR EO, et al. Hepatitis B, C, and D virus infections and AFP tumor marker prevalence among the elderly population in Mongolia: A nationwide survey[J]. J Prev Med Public Health, 2022, 55(3): 263-272. DOI: 10.3961/jpmph.21.573.
[24]	AFTAB M, NAZ S, AFTAB B, et al. Characterization of hepatitis delta virus among pregnant women of Pakistan[J]. Viral Immunol, 2019, 32(8): 335-340. DOI: 10.1089/vim.2019.0048.
[25]	BAHOUSSI AN, WANG PH, GUO YY, et al. Global distribution and natural recombination of hepatitis D virus: Implication of Kyrgyzstan emerging HDVs in the clinical outcomes[J]. Viruses, 2022, 14(7): 1467. DOI: 10.3390/v14071467.
[26]	HUSSEINI AA, ROSTAMZADEH M. Phylogenetic analysis and prevalence of Delta hepatitis among HBsAg carriers in Afghanistan[J]. Mol Biol Res Commun, 2022, 11(4): 183-186. DOI: 10.22099/mbrc.2022.44692.1780.
[27]	DAVAALKHAM D, OJIMA T, UEHARA R, et al. Hepatitis delta virus infection in Mongolia: analyses of geographic distribution, risk factors, and disease severity[J]. Am J Trop Med Hyg, 2006, 75(2): 365-369. DOI: 10.4269/ajtmh.2006.75.365
[28]	DELGERSAIKHAN ZO. Prevalence of HDV infection in Mongolia[C]//Falk Symposium, 2015.
[29]	KUSHNER T. Delta hepatitis epidemiology and the global burden of disease[J]. J Viral Hepat, 2023. DOI: 10.1111/jvh.13797.[Online ahead of print]
[30]	JOSEPH K, SHABANGU CS, JANG TY, et al. The prevalence and serological association of hepatitis D virus genotypes in Taiwan[J]. Pathogens, 2021, 10(10): 1227. DOI: 10.3390/pathogens10101227.
[31]	SAGNELLI C, SAGNELLI E, RUSSO A, et al. HBV/HDV co-infection: Epidemiological and clinical changes, recent knowledge and future challenges[J]. Life (Basel), 2021, 11(2): 169. DOI: 10.3390/life11020169.
[32]	LOUREIRO D, CASTELNAU C, BED CM, et al. Delta hepatitis: Epidemiology, diagnostic, natural history and treatment[J]. Rev Med Interne, 2022, 43(3): 160-169. DOI: 10.1016/j.revmed.2021.10.329.
[33]	KARLSEN AA, KYUREGYAN KK, ISAEVA OV, et al. Different evolutionary dynamics of hepatitis B virus genotypes A and D, and hepatitis D virus genotypes 1 and 2 in an endemic area of Yakutia, Russia[J]. BMC Infect Dis, 2022, 22(1): 452. DOI: 10.1186/s12879-022-07444-w.
[34]	WATANABE H, NAGAYAMA K, ENOMOTO N, et al. Chronic hepatitis delta virus infection with genotype Ⅱb variant is correlated with progressive liver disease[J]. J Gen Virol, 2003, 84(Pt 12): 3275-3289. DOI: 10.1099/vir.0.19499-0.
[35]	ROULOT D, BRICHLER S, LAYESE R, et al. Origin, HDV genotype and persistent viremia determine outcome and treatment response in patients with chronic hepatitis delta[J]. J Hepatol, 2020, 73(5): 1046-1062. DOI: 10.1016/j.jhep.2020.06.038.