丁型肝炎流行病学筛查检测指标及适宜人群

迟秀梅; 牛俊奇

doi:10.3969/j.issn.1001-5256.2023.04.006

丁型肝炎流行病学筛查检测指标及适宜人群

DOI: 10.3969/j.issn.1001-5256.2023.04.006

迟秀梅¹,
牛俊奇^2, , ,

1.
吉林大学第一医院基因治疗实验室，感染性疾病与病原生物学中心，长春 130061
2.
吉林大学第一医院肝病科，感染性疾病与病原生物学中心，长春 130021

基金项目:

国家自然科学基金 (81970519);

吉林省自然科学基金 (YDZJ202201ZTYS016)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：迟秀梅负责查阅文献，收集资料，撰写文稿；牛俊奇负责拟定写作思路，修改审阅文稿及最后定稿。

详细信息

通信作者:
牛俊奇，junqiniu@jlu.edu.cn (ORCID: 0000-0001-5415-2024)

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出版历程
- 收稿日期: 2023-02-09
- 录用日期: 2023-03-09
- 出版日期: 2023-04-20

Epidemiological screening and detection indicators for hepatitis D and suitable populations

Xiumei CHI¹,
Junqi NIU^{2
, ,
,}

1.
Gene Therapy Laboratory, Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun 130061, China
2.
Department of Hepatology, Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun 130021, China

Research funding:

National Natural Science Foundation of China (81970519);

Natural Science Foundation of Jilin Province (YDZJ202201ZTYS016)

More Information

Corresponding author: NIU Junqi, junqiniu@jlu.edu.cn (ORCID: 0000-0001-5415-2024)

摘要

摘要: HDV感染需要借助HBV的参与，感染后会加速疾病的进展，具有很高的发展为肝硬化、肝癌等终末期肝病的风险。近年来全社会对丁型肝炎的认识逐渐增强，一些针对丁型肝炎的治疗药物也成为研究的热点，伴随着临床检验手段的逐步完善，对于丁型肝炎的流行病学调查开始被研究者重视。针对国内HDV感染的具体情况虽已有多项研究，但由于研究队列小、区域性强而数据偏差较大。本文就目前丁型肝炎流行病学调查中的调查人群及调查方法检测指标等进行简要综述，并对其中的关键问题进行讨论，以期未来获取更准确的流行病学资料，能够更有效地筛查HDV感染者，为临床早期的干预和治疗提供帮助。
- δ肝炎病毒 /
- 流行病学 /
- 诊断技术和方法
Abstract: Hepatitis D virus (HDV) infection requires the participation of hepatitis B virus (HBV), which accelerates disease progression after infection and induces a high risk of progression to end-stage liver diseases such as liver cirrhosis and liver cancer. With the gradual increase in the understanding of hepatitis D in the whole society, some therapeutic drugs for hepatitis D have become a research hotspot in recent years, and with the further improvement in clinical testing methods, researchers have started to pay attention to the epidemiological investigation of hepatitis D. Although many studies have been conducted for the specific situation of HDV infection in China, large data deviation is observed due to small cohorts with strong regional features. This article briefly reviews the population, methods, and indicators in the current epidemiological investigation of hepatitis D and discusses related key issues, in order to obtain more accurate epidemiological data, effectively screen out HDV infection, and provide help for early clinical intervention and treatment.
- Hepatitis Delta Virus /
- Epidemiology /
- Diagnostic Techniques and Procedures

HTML全文

图 1 丁型肝炎筛查流程图

Figure 1. Hepatitis D screening flowchar

下载: 全尺寸图片幻灯片

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