肝脏疾病中内质网应激与铁死亡的关系

叶露; 李秀芹; 王建青

doi:10.3969/j.issn.1001-5256.2023.04.036

肝脏疾病中内质网应激与铁死亡的关系

DOI: 10.3969/j.issn.1001-5256.2023.04.036

叶露^{1, 2, 3},
李秀芹^{1, 2},
王建青^{1, 2, , ,}

1.
安徽医科大学第一附属医院药学部，合肥 230012
2.
安徽省公共卫生临床中心，合肥 230012
3.
安徽医科大学药学院，合肥 230032

基金项目:

国家自然科学基金 (82073566);

安徽省高校优秀青年人才支持计划资助项目 (gxyq2019014);

临床药学与药理学共建项目 (2020)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：叶露负责查阅文章，撰写论文；李秀芹、王建青负责修改文章并最后定稿。

详细信息

通信作者:
王建青，jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)

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出版历程
- 收稿日期: 2022-08-24
- 录用日期: 2022-10-08
- 出版日期: 2023-04-20

Association between endoplasmic reticulum stress and ferroptosis in liver diseases

Lu YE^{1, 2, 3},
Xiuqin LI^{1, 2},
Jianqing WANG^{1, 2
, ,
,}

1.
Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230012, China
2.
Anhui Public Health Clinical Center, Hefei 230012, China
3.
School of Pharmacy, Anhui Medical University, Hefei 230032, China

Research funding:

National Natural Science Foundation of China (82073566);

The Program of Excellent Young Talents in Universities of Anhui Province (gxyq2019014);

Clinical Pharmacy and Pharmacology (2020)

More Information

Corresponding author: WANG Jianqing, jianqingwang81@126.com (ORCID: 0000-0002-7935-9520)

摘要

摘要: 肝脏疾病的发病机制研究一直广受关注。内质网应激(ERS)是细胞的一种自我保护机制，但持续、严重的应激可诱导凋亡、自噬和铁死亡。其中，铁死亡作为近年研究热点，主要特征为铁依赖性脂质过氧化物的积累，在肝脏疾病的发生发展中发挥着关键作用，但目前关于肝脏疾病中ERS参与铁死亡的相关研究尚少。本文归纳了ERS相关信号通路和铁死亡的发生机制及其在肝脏疾病中的研究进展，为肝病治疗研究提供更多方向。
- 肝疾病 /
- 内质网应激 /
- 铁死亡
Abstract: Research on the pathogenesis of liver diseases has attracted great attention. Endoplasmic reticulum stress (ERS) is a self-protective mechanism of cells, but sustained and severe ERS can induce apoptosis, autophagy, and ferroptosis, among which ferroptosis has been a research hotspot in recent years. Ferroptosis is mainly characterized by the accumulation of iron-dependent lipid peroxides and plays a key role in the development and progression of liver diseases, but there are currently few studies on the involvement of ERS in ferroptosis in liver diseases. This article summarizes the research advances in ERS-related signaling pathways, the mechanism of ferroptosis, and the involvement of ERS in liver diseases, so as to provide more ideas for research on the treatment of liver diseases.
- Liver Diseases /
- Endoplasmic Reticulum Stress /
- Ferroptosis

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图 1 肝脏疾病中ERS与铁死亡的关系

Figure 1. Relationship between endoplasmic reticulum stress and ferroptosis in liver diseases

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