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非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析

段晓燕 范建高

段晓燕, 范建高. 非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析[J]. 临床肝胆病杂志, 2011, 27(4): 382-386.
引用本文: 段晓燕, 范建高. 非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析[J]. 临床肝胆病杂志, 2011, 27(4): 382-386.
Duan XiaoYan, Fan JianGao. Meta-analysis of 111 patients with nonalcoholic steatohepatitis-associated hepatocellular carcinoma[J]. J Clin Hepatol, 2011, 27(4): 382-386.
Citation: Duan XiaoYan, Fan JianGao. Meta-analysis of 111 patients with nonalcoholic steatohepatitis-associated hepatocellular carcinoma[J]. J Clin Hepatol, 2011, 27(4): 382-386.

非酒精性脂肪性肝炎相关肝细胞癌111例临床荟萃分析

详细信息
  • 中图分类号: R735.7

Meta-analysis of 111 patients with nonalcoholic steatohepatitis-associated hepatocellular carcinoma

  • 摘要: 目的总结非酒精性脂肪性肝炎(NASH)基础上肝癌的临床特征。方法对以"fatty liver、NASH、liver cancer、HCC"等为关键词,在Pubmed、Medline、OVID数据库检索得到的1990至2010年发表的22篇文献中111例NASH基础上肝癌患者的临床资料进行汇总分析。结果 (1)发现肝功能异常的年龄为60岁,诊断NASH的年龄为63.9岁,诊断肝细胞癌(HCC)的年龄66.7岁;(2)男性占62%,男女之比1.64:1;(3)79%患者伴有肥胖,78%伴有糖尿病,33%伴有血脂异常,52%伴有高血压;(4)71%患者肿瘤为单发,肿瘤直径最小1.0 cm,最大13 cm(平均3.3 cm);(5)大多数肿瘤发生在肝右叶;(6)67%HCC伴肝硬化,肿瘤组织以梁索型居多,分化程度多为良好~中分化;(7)多数患者无任何症状,常规体检时发现肿瘤;(8)65%病例AFP和/或PIVKAII升高;(9)大多数病例经手术切除治疗,术后平均随访24个月,21%患者死亡,15%复发。结论 NASH基础上HCC多见于男性,这类患者往往伴有代谢性疾病,尽管肿瘤分化程度较高,根治...

     

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  • 刊出日期:  2011-04-20
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