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IRIS13C-美沙西汀呼气试验与Child-Pugh分级、MELD评分评估肝硬化患者肝功能的比较

刘芳 向慧玲 韩涛 张翔

刘芳, 向慧玲, 韩涛, 张翔. IRIS13C-美沙西汀呼气试验与Child-Pugh分级、MELD评分评估肝硬化患者肝功能的比较[J]. 临床肝胆病杂志, 2012, 28(9): 661-666.
引用本文: 刘芳, 向慧玲, 韩涛, 张翔. IRIS13C-美沙西汀呼气试验与Child-Pugh分级、MELD评分评估肝硬化患者肝功能的比较[J]. 临床肝胆病杂志, 2012, 28(9): 661-666.
Liu Fang, Xiang HuiLing, Han Tao, Zhang Xiang. Clinical value of 13C-methacetin breath test for assessing liver function in patients with cirrhosis[J]. J Clin Hepatol, 2012, 28(9): 661-666.
Citation: Liu Fang, Xiang HuiLing, Han Tao, Zhang Xiang. Clinical value of 13C-methacetin breath test for assessing liver function in patients with cirrhosis[J]. J Clin Hepatol, 2012, 28(9): 661-666.

IRIS13C-美沙西汀呼气试验与Child-Pugh分级、MELD评分评估肝硬化患者肝功能的比较

详细信息
  • 中图分类号: R575.2

Clinical value of 13C-methacetin breath test for assessing liver function in patients with cirrhosis

  • 摘要: 目的通过比较肝硬化患者13C-美沙西汀呼气试验、Child-Pugh分级及MELD评分,结合腹部CT测量肝脾体积以探讨13C-美沙西汀呼气试验评价肝脏储备和代偿功能的临床应用价值。方法 139例肝硬化患者行13C-美沙西汀呼气试验、Child-Pugh分级及MELD评分,分析各组13C-美沙西汀呼气试验的呼气参数值之间的相互关系,比较乙型肝炎肝硬化患者肝脏、脾脏体积变化以进一步评估13C-美沙西汀呼气试验反映肝细胞储备和代偿功能的作用。结果13C-美沙西汀呼气试验肝脏功能分级与肝硬化患者传统的Child-Pugh分级判定肝功能状况具有良好一致性(κ=0.55,P<0.05),与MELD评分比较具有一致性(κ=0.41,P<0.05);肝脏病变程度越重,13C-美沙西汀呼气试验量化值越小,肝硬化患者呼气参数值显著下降(P<0.05),肝细胞储备和代偿功能越差;呼气试验参数与Child-Pugh分级计分、MELD评分、血清总胆红素、国际标准化比值(INR)呈明显负相关(P<0.01),与血清白蛋白、前白蛋白、凝血酶原活动度、胆碱酯酶呈正相关(P<0.01),与...

     

  • [1]蒋忠胜, 江建宁.CTP和MELD评分预测慢性重型肝炎预后的临床价值[J].中国危重病急救医学, 2007, 19 (3) :412-415.
    [2]占国清, 郑三菊, 朱琳, 等.终末期肝病模型及Child-Pugh分级对失代偿期肝硬化患者的预后分析[J].临床肝胆病杂志, 2007, 25 (2) :114-116.
    [3]刘斌, 亓玉忠, 刘佳宁, 等.MELD评分对肝硬化患者腹腔镜胆囊切除术手术风险的预测价值[J].中国普通外科杂志, 2010, 19 (2) :172-175.
    [4]吕晓辉, 刘红波, 宋敏, 等.终末期肝病模型对失代偿期肝硬化患者预后的回顾性分析[J].世界华人消化杂志, 2007, 15 (9) :960-963.
    [5]赵玉石, 韩德恩, 邰升, 等.MELD评分评估肝硬化肝功能储备力的临床研究[J].中华肝胆外科杂志, 2007, 13 (9) :585-587.
    [6]盛国平, 李兰娟.终末期肝病模型在肝病中的应用进展[J].国际流行病学传染病学杂志, 2006, 33 (1) :68-70.
    [7]Huo TL, Wang YW, Yang YY, et al.Model for end-stageliver disease score to serum sodium ratio index as a prognos-tic predictor and its correlation with portal pressure in patientswith liver cirrhosis[J].Liver Int, 2007 (4) , 498-506.
    [8]Luca A, Angermayr B, Bertolini G, et al.An integrated MELDmodel including serum sodium and age improves the predictionof early mortality in patients with cirrhosis[J].Liver Transplant, 2007, 13 (8) :1174-1180.
    [9]Martin AP, Bartels M, Hauss J, et al.Overview of the MELDscore and the UNOS adult liver allocation system[J].TransplantProc, 2007, 39 (10) :3169-3174.
    [10]Cucchetti A, Cucchetti A, Ercolani G, et al.Impact of modelfor end-stage liver disease (MELD) score on prognosis afterhepatectomy for hepatocellular carcinoma on cirrhosis[J].Liver Transplant, 2006, 12 (6) :966-971.
    [11]Huo TI, Lee PC, Huang YH, et al.The sequential changesof the model for end-stage liver disease score correlatewith the severity of liver cirrhosis in patients with hepatocel-lular carcinoma undergoing locoregional therapy[J].J ClinGastroenterol, 2006, 40 (5) :543-550.
    [12]Huo TI, Lin HC, Wu JC, et al.Limitation of the model forend-stage liver disease for outcome prediction in patientswith cirrhosis-related complications[J].Clin Transplant, 2006, 20 (2) :188-194.
    [13]Gotthard TD, Weiss KH, Baumgartner M, et al.Limitationsof the MELD score in predicting mortality or need for removalfrom waiting list in patients awaiting liver transplantation[J].BMC Gastroenterol, 2009, 9 (72) :1-7.
    [14]严德辉, 雷俊阳, 陶涛, 等.Child-Pugh分级、终末期肝病模型与肝硬化患者术后并发症的关系[J].肝胆外科杂志[J], 2008, 16 (1) :48-49.
    [15]Lalazar G, Adar T, Ilan Y.Point-of-care continuous 13C-methacetin breath test improves decision making in acute liv-er disease:Results of a pilot clinical trial[J].World J Gas-troenterol, 2009, 15 (8) :966-972.
    [16]Lalazar G, Pappo O, Hershcovici T, et al.A continuous 13Cmethacetin breath test for noninvasive assessment of intra-hepatic inflammation and fibrosis in patients with chronic HCVinfection and normal ALT[J].J Viral Hepat, 2008, 15 (8) :716-728.
    [17]Wutzke K, Forberger A, Wigger M.Effect of alcohol consump-tion on the liver detoxication capacity as measured by[13C]methacetin-and[methyl-13C]methionine-breath tests[J].Isotopes Environ Health Stud, 2008, 44 (2) :219-226.
    [18]Lalazar G, Braun M, Ben Ari Z, et al.The non-invasive13C-methacetin breath test accurately detects liver fibrosis inpatients with chronic HCV infection or non-alcoholic fatty liv-er disease[J].J Hepatol, 2007, 46 (S209) .
    [19]Dinesen L, Caspary W, Chapman R, et al.13C-methacetin-breath test compared to also noninvasive biochemicalblood tests in predicting hepatic fibrosis and cirrhosis in chro-nic hepatitis C[J].Dig Liver Dis, 2008, 40 (9) :743-748.
    [20]Goetze O, Selzner N, Fruehauf H, et al.13C-methacetinbreath test as a quantitative liver function test in patients withchronic hepatitis C infection:continuous automatic molecularcorrelation spectroscopy compared to isotopic ratio mass spec-trometry[J].Aliment Pharmacol Ther, 2007, 26 (3) :305-311.
    [21]林言, 宋震亚, 范燕萍, 等.IRIS13C-美沙西汀汀呼气试验在肝硬化患者中的应用及评价[J].临床肝胆病杂志, 2008, 24 (1) :96-98.
    [22]陈燕敏, 李建阳, 任森洋.13C-美沙西汀汀呼气试验对肝硬化患者肝脏储备功能的临床研究[J].浙江实用医学, 2008, 13 (1) :79-81.
    [23]王萱, 薛华丹, 刘炜, 等.肝脏体积与各种生理参数及不同肝功能评分间的关系[J].中国医学科学院学报, 2009, 31 (2) :237-241.
    [24]Zhou XP, Lu T, Wei YG, et al.Liver volume variation in pa-tients with virus-induced cirrhosis:findings on MDCT[J].AJR Am J Roentgenol, 2007, 189 (3) :W153-W159.
    [25]黎一鸣, 李华, 吉鸿, 等.D山梨醇肝清除率联合CT肝体积测量评价病肝储备功能[J].中国普外基础与临床杂志, 2009, 16 (4) :285-289.
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  • 刊出日期:  2012-09-20
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