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改良式经皮肝动脉化疗药盒植入技术中国专家共识(2022版)

基金项目: 

北京市医管局“扬帆”计划重点医学专业项目 ZYLX202117;

国家自然科学基金 82172039

    王晓东(北京大学肿瘤医院),xiaodongw75@yahoo.com;杨仁杰(北京大学肿瘤医院),renjieyang2007@163.com;邹英华(北京大学第一医院),cjr.zouyinghua@vip.163.com

Chinese expert consensus on the modified implantation technique of port-catheter system for percutaneous hepatic arterial infusion chemotherapy(version 2022)

Research funding: 

Key Medical Specialty Development Program (Yangfan Program) of Beijing Hospital Authority ZYLX202117;

National Natural Science Foundation of China 82172039

  • 摘要: 近年来,肝动脉灌注化疗(HAIC)作为介入治疗技术之一,应用于治疗进展期肝胆恶性肿瘤的效果逐渐受到认可。但不同临床中心的HAIC操作技术差别较大,缺乏行业规范,且多数以一次性穿刺留管形式完成。为了满足HAIC需长时间持续灌注、多次反复给药的特点,经皮肝动脉化疗药盒系统比一次性穿刺留管更具优势。改良式经皮肝动脉化疗药盒系统植入术采用管头固定技术、肝内外血流再分布术,具有创伤小、导管移位率低、实现全肝灌注、患者舒适性高、并发症少等优点,已在国内外多个临床中心得以证实。为了更好地规范HAIC治疗技术,通过回顾文献并经临床实践和充分讨论,参与本共识编写专家达成改良式经皮肝动脉化疗药盒植入术标准化操作流程、技术要点、HAIC方案、术后并发症防治、药盒系统维护及相关护理常规等共识。

     

  • 图  1  肝外血流再分布术

    注:▲①腹腔动脉造影示胃右动脉(白虚线箭)从肝左动脉起始部发出,副胃左动脉(白实线箭)从肝左动脉二级分支处发出;②采用微弹簧圈超选择行胃右动脉和副胃左动脉(黑虚线箭)栓塞,胃十二指肠动脉(gastroduodenal artery,GDA)固定管头时栓塞(橙色箭),经药盒留置导管行肝动脉造影显示肝动脉分支显示完全,未见胃肠道动脉分支显示;▲③腹腔动脉造影示肝固有动脉发出十二指肠后上动脉(白实线箭)和胃右动脉(白虚线箭);④采用微弹簧圈超选择行胃右动脉和十二指肠后上动脉(黑虚线箭)栓塞,GDA固定管头时栓塞(橙色箭),经药盒留置导管行肝动脉造影示肝动脉分支显示完全,未见胃肠道动脉分支显示;▲经胃左动脉逆行栓塞胃右动脉:⑤经胃左动脉(白虚线箭)逆行超选择微导管至胃右动脉起始部(白实线箭)造影示胃右动脉;⑥微弹簧圈栓塞胃右动脉(黑实线箭),经药盒行肝动脉造影示胃右动脉闭塞,肝动脉显示完全。

    Figure  1.  Extrahepatic blood flow redistribution

    图  2  肝内血流再分布术

    注:①腹腔动脉造影示副肝左动脉(白箭)从胃左动脉发出;②微弹簧圈栓塞变异的副肝左动脉(白虚线箭)后,经药盒留置导管造影示肝固有动脉供血全肝;③术中肝总动脉造影示肝总动脉仅发出部分肝动脉;④肠系膜上动脉造影示副肝右动脉(白箭)从肠系膜上动脉发出;⑤胃左动脉造影示副肝左动脉(黑箭)从胃左动脉发出;⑥微弹簧圈分别栓塞副肝右动脉(白虚线箭)和副肝左动脉(黑虚线箭)后,经药盒留置导管造影示肝固有动脉供血全肝。

    Figure  2.  Intrahepatic blood flow redistribution

    图  3  管头固定技术模式图

    Figure  3.  Fixed-catheter-tip technical pattern

    图  4  管头固定技术

    注:①留置导管远端(白实线箭)选择性进入GDA,微导管(黑实线箭)通过留置导管侧孔(白箭头)进入GDA;②通过微导管在GDA内、留置导管远端(黑箭头)外侧,密集释放微弹簧圈(白箭头);③微导管导丝(黑实线箭)通过留置导管(黑箭头)内腔,进入GDA;④通过微导管释放微弹簧圈(黑实线箭),封堵留置导管远端端孔(白箭头);⑤⑥栓塞固定留置导管远端于GDA(白实线箭)的同时栓塞胰十二指肠后上动脉(黑实线箭和黑虚线箭)。

    Figure  4.  Fixed-catheter-tip technique

    图  5  药盒埋置位置

    注:①股动脉入路;②锁骨下动脉入路。

    Figure  5.  Position of the implantation of port-catheter system

    图  6  DSA和CTHA造影明确药盒功能状态

    注:①②经药盒行肝动脉DSA和CTHA造影显示肝脏灌注完全,未见肝外异常灌注。

    Figure  6.  Functional status of port-catheter system determined by DSA and CTHA

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    康志龙, 杨仁杰. 动脉导管药盒系统在肿瘤介入治疗中的应用进展[J]. 临床肿瘤学杂志, 2010, 15(10): 952-954. DOI: 10.3969/j.issn.1009-0460.2010.10.020.
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  • 收稿日期:  2022-09-24
  • 录用日期:  2022-10-13
  • 出版日期:  2022-11-20
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