Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

Jing LI; Jing XIA; Jie WU

doi:10.3969/j.issn.1001-5256.2021.10.023

Volume 37 Issue 10

Oct. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(10): 2376-2379

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Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

Jing LI¹,
Jing XIA¹,
Jie WU^{1, 2
,
,}

1.
Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China
2.
Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China

Received Date: 2021-02-21
Accepted Date: 2021-03-15
Published Date: 2021-10-20

Abstract

Abstract

Objective To investigate the correlation of the levels of fat-soluble vitamins (FSVs) with the changes of related indicators in infants with cholestatic liver disease, and to provide a basis for the supplementation of FSVs in infants with cholestatic liver disease. Methods A total of 136 children with cholestatic liver disease who were hospitalized in Department of Pediatric Gastroenterology, Shengjing Hospital of China Medical University, from January 2018 to December 2020 were enrolled as observation group, and 30 healthy infants who underwent physical examination in our hospital during the same period of time were enrolled as control group. Related data were recorded, including gestational age, age in days, sex, and etiology, and related examinations were performed, including liver function, serum calcium, serum phosphorus, coagulation function, etiology, radiological examination, and gene detection. The serum levels of vitamins A, D, E, and K were also measured. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups, and the chi-square test was used for comparison of categorical data between groups. Results There were significant differences in the levels of FSVs between the observation group and the control group (vitamin A: Z=-2.850, P= 0.004; vitamin D3: Z=-5.705, P < 0.001; vitamin E: Z=-5.894, P < 0.001; vitamin K: Z=-2.482, P= 0.013), and there were no significant differences in the levels of FSVs between the full-term infants and the preterm infants (all P > 0.05). Serum total bilirubin was significantly correlated with vitamins A and D3 (vitamin A: r=-0.178, P=0.038; vitamin D3: r=-0.296, P < 0.001), and serum direct bilirubin and total bile acid were significantly correlated with vitamin D3 (r=-0.328 and -0.194, both P < 0.05); serum alkaline phosphatase was significantly correlated with vitamins A and D3 (vitamin A: r=-0.282, P= 0.001; vitamin D3: r=-0.514, P < 0.001). Serum vitamin D3 level was positively correlated with serum calcium (r=0.303, P < 0.001) and phosphorus (r=0.310, P < 0.001) and was negatively correlated with alkaline phosphatase (r=-0.514, P < 0.001). There was no significant correlation between serum vitamin K level and coagulation markers (all P > 0.05), while there was a significant change in vitamin K level after treatment (Z=-5.662, P < 0.001). Conclusion The levels of FSVs in children with cholestatic liver disease are significantly lower than those in healthy infants of the same age in days. An increase in serum total bilirubin can indicate the deficiency of vitamins A and D3; increases in serum direct bilirubin and total bile acid can indicate vitamin D3 deficiency; an increase in serum alkaline phosphatase can indicate the deficiency of vitamins A and D3.
- Cholestasis,
- Vitamins,
- Infant

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Correlation of the levels of fat-soluble vitamins with biochemical parameters in infants with cholestatic liver disease

DOI: 10.3969/j.issn.1001-5256.2021.10.023

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