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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 7
Jul.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(7): 1572-1576

A prognostic analysis of transcatheter arterial chemoembolization combined with local ablation in treatment of recurrent liver cancer after surgery

DOI: 10.3969/j.issn.1001-5256.2022.07.021
  • 1.

    Graduate School of Ningxia Medical University, Yinchuan 750004, China

  • 2.

    Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Kunming Medical University, Kunming 650100, China

  • 3.

    Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan 750003, China

Research funding:

Natural Science Foundation of Ningxia Province (2019AAC03192);

Key R & D Project of Ningxia Science and Technology Department (2020BEG03004);

Special Project of Science and Technology benefiting the People of Ningxia Hui Autonomous Region (2021CMG03014);

Special Project of Science and Technology benefiting the People of Ningxia Hui Autonomous Region (2021CMG03015);

Ningxia Hui Autonomous Region Science and Technology Infrastructure Construction Plan Innovation Platform Fund (2020CXPT0007)

More Information
  • Corresponding author: LU Zhenhui, zhenhuilu@hotmail.com(ORCID: 0000-0003-3509-7837)
  • Received Date: 2021-11-14
  • Accepted Date: 2021-12-20
  • Published Date: 2022-07-20
    Abstract
  •   Objective  To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) combined with local ablation in the treatment of recurrent liver cancer after surgery, as well as the risk factors for prognosis.  Methods  A retrospective analysis was performed for the data of 47 patients with recurrent liver cancer after surgery who received TACE combined with local ablation in General Hospital of Ningxia Medical University from January 2017 to December 2020. The patients were followed up after local ablation to assess short-term outcome and survival. Univariate and multivariate analyses were used to investigate the factors affecting prognosis; the Kaplan-Meier model and the log-rank test were used for univariate analysis, and the Cox proportional-hazards regression model was used for multivariate analysis.  Results  At 3 months after treatment, the 47 patients with recurrent liver cancer after surgery had an overall effective rate of 89.3% and a disease control rate of 95.7%, and the overall survival rates at 6, 12, 18, and 24 months were 95.70%, 76.40%, 63.30%, and 58.00%, respectively. The univariate analysis and the Cox proportional-hazards regression analysis showed that irregularity of tumor boundary (risk ratio [RR]=3.938, 95% confidence interval [CI]: 1.709-9.073, P=0.005) and proximity of tumor to risk areas (major blood vessels and hollow visceral organs, etc.) (RR=3.202, 95% CI: 1.415-7.245, P=0.001) were associated with postoperative survival.  Conclusion  TACE combined with local ablation is an effective treatment modality for recurrent liver cancer after surgery, and irregularity of tumor boundary and proximity of tumor to risk areas (major blood vessels and hollow visceral organs, etc.) are the risk factors affecting the postoperative survival of such patients.

     

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