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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 7
Jul.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(7): 1595-1601

Influence of fatty liver on the severity of acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2022.07.025

  • Department of Medical Imaging, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region 014010, China

Research funding:

Seeding Project of Baotou Medical College (BYJJ-QM-201753)

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  • Corresponding author: CHEN Qiang, xy198033@sina.com (ORCID: 0000-0002-0864-4287)
  • Received Date: 2021-11-26
  • Accepted Date: 2022-02-14
  • Published Date: 2022-07-20
    Abstract
  •   Objective  To investigate the influence of fatty liver on the severity of acute pancreatitis (AP) by comparing clinical and imaging data between AP patients with fatty liver and those without fatty liver.  Methods  Clinical data were collected from 328 AP patients who were admitted to The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, from December 2017 to May 2020, and according to the presence or absence of fatty liver, they were divided into fatty liver+AP group (FLAP group) and non-fatty liver AP group (NFLAP group). The two groups were compared in terms of the indices such as general information, laboratory markers, and chronic diseases. The chi-square test was used to compare the rates of binary variables, and the t-test or the Mann-Whitney U test was used for comparison of continuous variables. The Pearson liner correlation analysis was used to investigate the correlation between continuous variables, and the Spearman rank correlation analysis was used to investigate the correlation between rank variables. The multivariate logistic regression analysis and the chi-square test were used to investigate the influencing factors and possible risk predictive factors for moderate-severe AP (MSAP) and severe AP (SAP).  Results  Among the 328 AP patients enrolled, there were 133(40.55%) in the FLAP group and 195(59.45%) in the NFLAP group. Hyperlipidemia (42.1%) was the main cause of AP, followed by gallstone disease (39.3%). Compared with the NFLAP group, the FLAP group had a significantly lower mean age (41.32±11.43 years vs 54.83±15.21 years, t=8.704, P < 0.001) and significantly higher proportion of male patients (78.95% vs 55.38%, χ2=19.281, P < 0.001), proportion of patients with chronic disease (70.68% vs 45.64%, χ2=20.094, P < 0.001), and incidence rate of MSAP+SAP (59.40% vs 41.03%, χ2=10.686, P < 0.01). Compared with the NFLAP group, the FLAP group had significantly higher levels of triglyceride, total cholesterol, fasting blood glucose, and C-reactive protein on days 1 and 2 after admission (Z=-8.216, -5.637, -4.001, -3.053, and -3.325, all P < 0.05), as well as significantly lower levels of blood amylase, blood lipase, high-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, and total bilirubin (Z=-5.401, -2.842, -3.594, -2.276, -2.643, and -2.339, all P < 0.05). Patients with a relatively young age (< 50 years) (odds ratio [OR]=1.84, 95% confidence interval [CI]: 1.18-2.89, P < 0.01) and a past history of hypertension (OR=3.58, 95%CI: 1.96-6.54, P < 0.001) or hyperlipidemia (OR=3.36, 95%CI: 1.03-10.94, P < 0.05) had a relatively high risk of MSAP+SAP. The FLAP group had a significantly higher risk of MSAP+SAP than the NFLAP group (OR=2.10, 95%CI: 1.34-3.29, P < 0.01).  Conclusion  FLAP patients often have a relatively young age of onset, hyperlipidemia, and a relatively high proportion of patients with MSAP+SAP. Fatty liver is not only an influencing factor for MSAP+SAP, but also an important predictive factor for the risk of MSAP+SAP.

     

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