中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 7
Jul.  2022
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Article Contents

The significance of gut microbiota in acute-on-chronic liver failure

DOI: 10.3969/j.issn.1001-5256.2022.07.040
Research funding:

National Natural Science Foundation of China (81800528);

Natural Science Foundation of Gansu Province (20JR5RA364);

Hospital fund of the First Hospital of Lanzhou University (ldyyyn2020-02);

Hospital fund of the First Hospital of Lanzhou University (ldyyyn2020-14);

Gansu Clinical Medical Research Center of Infection & Liver Diseases (21JR7RA392)

More Information
  • Various acute injury factors may act on chronic liver diseases and then lead to the rapid deterioration of disease conditions, which further develops into acute-on-chronic liver failure (ACLF). In patients with liver disease, gut microbiota toxins enter the liver through the portal vein or systemic circulation and thus lead to the death of hepatocytes; in addition, gut microbiota translocation occurs through various mechanisms, induces infection, vasodilation, and systemic inflammation, and then promotes disease progression to decompensated liver cirrhosis and ACLF, which ultimately endangers the life of patients. This article summarizes related research findings in the recent five years and elaborates on the significance of gut microbiota in the development, progression, prevention, and treatment of ACLF. Gut microbiota and its metabolites have a significant impact on the progression of liver disease, and therefore, it is necessary to conduct in-depth studies on the role of gut microbiota in the etiology of ACLF, in order to provide new ideas for the diagnosis and treatment of ACLF.

     

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