Do HBV DNA-negative HBsAg-positive patients with compensated hepatitis B cirrhosis need antiviral therapy?

Li SU; Jinghang XU; Yaomin LIU; Guomin ZHANG; Yuting GUO; Guiqiang WANG

doi:10.3969/j.issn.1001-5256.2023.01.006

Volume 39 Issue 1

Jan. 2023

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Do HBV DNA-negative HBsAg-positive patients with compensated hepatitis B cirrhosis need antiviral therapy?

DOI: 10.3969/j.issn.1001-5256.2023.01.006

1.
Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China
2.
Department of Infectious Diseases, The Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, China
3.
First Department of Hepatology, The Third People's Hospital of Linfen City, Linfen, Shanxi 041000, China

Research funding:

Early Clinical Trials and Key Technologies of Innovative Drugs for Liver Diseases by Beijing Municipal Science and Technology Commission (Z191100007619037)

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Corresponding author: WANG Guiqiang, John131212@sina.com (ORCID: 0000-0002-0317-7536)
Received Date: 2022-08-21
Published Date: 2023-01-20

Abstract

Abstract

Hepatitis B virus (HBV) infection is a common cause of liver disease in China, and with the continuous progress in the research on antiviral therapy for chronic hepatitis B, the indications for antiviral therapy are constantly expanding. However, there are still controversies over the indications for antiviral therapy in patients with chronic hepatitis B (CHB), especially those with negative HBV. By analyzing the limitations of HBV DNA detection, the risk of HBV reactivation in HBV-negative CHB patients, the risk of disease progression in the DNA-negative population with compensated hepatitis B cirrhosis, antiviral response, and the economic benefits of antiviral therapy, this article proposes the necessity of antiviral therapy for HBV-negative HBsAg-positive patients with compensated hepatitis B cirrhosis.
- Hepatitis B virus,
- Liver Cirrhosis,
- Therapeutics

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References(43)

References

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Do HBV DNA-negative HBsAg-positive patients with compensated hepatitis B cirrhosis need antiviral therapy?

DOI: 10.3969/j.issn.1001-5256.2023.01.006

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Do HBV DNA-negative HBsAg-positive patients with compensated hepatitis B cirrhosis need antiviral therapy?

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