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ISSN 1001-5256
CN 22-1108/R
Volume 39 Issue 1
Jan.  2023
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Article Contents

Clinical characteristics and prognosis of acute on chronic liver failure in patients with recompensatory hepatitis B cirrhosis

DOI: 10.3969/j.issn.1001-5256.2023.01.011
Research funding:

Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-034A;

Tianjin Health Project TJWJ2022XK029

More Information
  • Corresponding author: LIANG Jing, haolele77@sina.com(ORCID: 0000-0001-5114-9030)
  • Received Date: 2022-07-07
  • Accepted Date: 2022-08-26
  • Published Date: 2023-01-20
  •   Objective  To assess the clinical characteristics of acute-on-chronic liver failure in patients with recompensatory hepatitis B cirrhosis.  Methods  A total of 180 patients with acute-on-chronic liver failure hospitalized in Tianjin Third Central Hospital from September 2013 to September 2021 were retrospectively collected, with 110 patients had compensatory hepatitis B cirrhosis and 70 patients had compensatory hepatitis B cirrhosis and used as the control. Their causes, clinical biochemical indicators, complication rate, and prognosis were compared. The Chi-square test or Fisher's exact test was used for comparison of categorical variables between groups, and the Mann-Whitney U test was performed for analysis of the continuous variables. Kaplan-Meier curves and Log-rank test were used for survival of patients.  Results  The incidence of hepatorenal syndrome (χ2=4.618, P=0.032), infection (χ2=6.712, P=0.010), Cr (Z =-4.508, P < 0.001), and PCT (Z=-2.052, P=0.040) were all higher, whereas GGT (Z=-2.042, P=0.041), Na (Z=-2.001, P=0.045), FBS (Z=-3.065, P=0.002), and TC (Z=-4.268, P < 0.001) were all lower in the recompensation group than in the control group of patients. However, 90-day mortality rate (χ2=3.366, P=0.067) and 1-year mortality rate (χ2=1.893, P=0.169), 90-day survival (χ2=2.68, P=0.100), and 1-year survival (χ2=2.074, P=0.150) were not statistically significant difference.  Conclusion  Compared with compensatory hepatitis B cirrhosis, patients with recompensatory cirrhosis had an increased risk in developing hepatorenal syndrome, infection, and increased creatinine level after acute-on-chronic liver failure, although there was no statistically significant difference in 90-days and 1-year survival of patients.

     

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