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胃肠神经内分泌肿瘤和胰腺神经内分泌肿瘤的区别
Differentiation between gastrointestinal neuroendocrine tumors and pancreatic neuroendocrine tumors
文章发布日期:2013年06月07日  来源:  作者:李晓青,钱家鸣  点击次数:2579次  下载次数:683次

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【摘要】:胃肠胰神经内分泌肿瘤(GEP-NETs)主要来源于胃肠胰系统的神经内分泌细胞,这一细胞系统和肿瘤是以表达细胞类型特异的肽激素和普通标记物(突触囊泡蛋白、铬粒素A)为特征。其特点为:临床上少见;肿瘤通常较小(<1 cm);生长速度较慢(数月或数年),呈阶段性表达,可能数年无症状;通常在出现症状前即有转移,转移部位多为肝脏和骨,而此时肿瘤的体积通常>2 cm。因此这类肿瘤经常被误诊,诊断过程较复杂,不单单依靠临床,往往需要高端的实验室和扫描手段支持。而GEP-NETs中胃肠神经内分泌肿瘤(NET)和胰腺NET,两者在临床表现、诊断和治疗方面也有不同,需要临床医生重视和加以区分。
【Abstract】:Gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) are mainly derived from the neuroendocrine cells of the gastrointestinal-pancreatic system, which express cell type-specific peptide hormones and general markers (synaptic vesicle proteins and chromogranin A). GEP-NETs have the following characteristics: they are rarely seen in the clinical setting; the tumor sizes are usually small (<1 cm); tumors grow slowly (for months or years), with several stages of development, and they probably have no symptoms for years; metastases often occur before onset of symptoms, with the liver and bones commonly affected, and the tumor sizes are larger than 2 cm at this time. Thus, GEP-NETs are often misdiagnosed; the diagnostic process is complex, not only relying on clinical manifestations, but also advanced laboratory and scanning means. Moreover, gastrointestinal NETs and pancreatic NETs differ in clinical manifestations, diagnosis, and treatment, and clinicians need to pay more attention to differentiation between them.
【关键字】:神经内分泌瘤;胃肠肿瘤;胰腺肿瘤
【Key words】:neuroendocrine tumors; gastrointestinal neoplasms; pancreatic neoplasms
【引证本文】:

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