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胰腺癌早期诊断难点的思考
Discussion of difficult problems of early diagnosis of pancreatic cancer
文章发布日期:2014年06月26日  来源:  作者:郭晓钟,刘旭  点击次数:2233次  下载次数:451次

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【摘要】:胰腺癌恶性程度及病死率极高,目前针对早期胰腺癌的诊断方法仍不理想。分析早期胰腺癌诊断的难点,应重视不明原因的腹部和背部疼痛、黄疸以及突发糖尿病等临床预警症状。同时,应采用CA19-9、CEA等多种肿瘤标志物联合检测,关注生化检测指标,推广KAI1、p53等基因突变的检测,尤其是探索miRNA在临床诊断中的价值十分有意义。此外,应逐步采取超声、CT、磁共振以胆管造影术、经内镜逆行胰胆管造影、PET-CT等影像学检查方法,以及有效获取细胞学检测标本,以达到早期诊断胰腺癌的目的。
【Abstract】:Pancreatic cancer is a common malignant neoplasm of the pancreas with an extremely high mortality. Currently, the early diagnosis of pancreatic cancer is still not ideal. Attention should be paid to some clinical warning symptoms, such as unexplained abdominal and back pain, jaundice, and unexpected diabetes. Additionally, the combined use of CA19-9, CEA, and other tumor markers, the attention to biochemical indicators, the detection of mutation in KAI1 or p53 gene, and the exploration of the value of miRNA in clinical diagnosis are of great significance. On the other hand, ultrasound, CT, MRCP, ERCP, PET-CT, and other imaging methods, as well as effective collection of cytology specimens, should be performed. Thus, there is hope for the early diagnosis of pancreatic cancer.
【关键字】:胰腺肿瘤;早期诊断;综述
【Key words】:pancreatic neoplasms;early diagnosis;review
【引证本文】:

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