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非酒精性脂肪性肝病动物实验模型研究进展
Research advances in animal models of nonalcoholic fatty liver disease
文章发布日期:2014年09月12日  来源:  作者:黄海燕,辛永宁,姜曼,等  点击次数:1802次  下载次数:363次

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【摘要】:近年来随着肥胖、2型糖尿病、高脂血症等发生率的升高,非酒精性脂肪性肝病(NAFLD)的发病率也逐渐升高,成为常见的慢性肝脏疾病之一,而在我国是仅次于慢性病毒性肝炎的第二大肝病。但其发病机制仍未阐明,因NAFLD的发生和演进病程长,且从人体获取肝组织进行研究或药物试验等受伦理限制,因此NAFLD动物模型在本病研究中起了重要作用。综述了具备与NAFLD患者组织病理学表现相似的动物模型,并比较其建模原理及优缺点。为深入研究NAFLD发病机制,筛选防治药物等提供了有利工具。
【Abstract】:In recent years, the incidence of nonalcoholic fatty liver disease (NAFLD) has increased gradually along with the rising prevalence of obesity, type 2 diabetes, and hyperlipidemia, and NAFLD has become one of the most common chronic liver diseases in the world and the second major liver disease after chronic viral hepatitis in China. However, its pathogenesis has not yet been clarified. Animal models are playing an important role in researches on NAFLD due to the facts that the development and progression of NAFLD require a long period of time, and ethical limitations exist in conducting drug trials in patients or collecting liver tissues from patients. The animal models with histopathology similar to that of NAFLD patients are reviewed, and their modeling principle, as well as the advantages and disadvantages, are compared. Animal models provide a powerful tool for further studies of NAFLD pathogenesis and drug screening for prevention and treatment of NAFLD.
【关键字】:脂肪肝;疾病模型,动物;小鼠;综述
【Key words】:fatty liver; disease models, animal; mice; review
【引证本文】:

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