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肝硬化患者中高血压病患病率相关分析
Study on prevalence of hypertension in patients with liver cirrhosis
文章发布日期:2014年10月17日  来源:  作者:余灵祥,谭钧元,徐志伟,等  点击次数:1997次  下载次数:397次

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【摘要】:目的探讨肝硬化患者中高血压病的患病率情况,以及肿瘤坏死因子(TNFα)、胆碱酯酶(CHE)和P物质、一氧化氮(NO)、肾上腺髓质素(ADM)在其中的作用和意义。方法病例组纳入2013年3月-2014年2月入院的肝硬化患者134例;对照组纳入268例健康体检者,分别采集空腹血液样本并测定血清中TNFα、CHE、P物质、NO和ADM的值,对2组有高血压病患者的患病率以及上述指标进行比较。计量资料比较采用t检验,计数资料用卡方检验,等级资料采用Kruskal-Wallis H检验。结果肝硬化患者的高血压病的患病率为18.66%(25/134),低于普通人群的患病率30.97%(83/268)。肝硬化伴高血压组的血清TNFα、P物质、NO、ADM水平均高于对照组有高血压病患者(t=25.464、16.649、19.772、13.835,P值均<0.05),而血清CHE水平肝硬化伴高血压组低于对照组有高血压病患者(t=-50.257,P<0.05)。结论肝硬化患者高血压病的患病率低于普通人群,肝硬化的患者高血压患病率低可能与肝硬化患者扩血管因素如血清中升高的P物质、NO、ADM增多有关。
【Abstract】:ObjectiveTo investigate the prevalence of hypertension in patients with liver cirrhosis and its relationship with tumor necrosis factor alpha (TNFα), cholinesterase (CHE), substance P (SP), nitric oxide (NO), and adrenomedullin (ADM). MethodsA total of 134 cirrhotic patients newly admitted to the hospital were selected as case group, and 268 subjects undergoing physical examination were selected as control group. Fasting blood was collected, and serum levels of TNFα, CHE, SP, NO, and ADM were determined. The two groups were compared with respect to the prevalence of hypertension and serum levels of TNFα, CHE, SP, NO, and ADM. Comparison of measurement data was made by t test, comparison of enumeration data was made by chi-square test, and comparison of ranked data was made by Kruskal-Wallis H test. ResultsThe prevalence of hypertension for the case group (18.66%, 25/134) was lower than that for the control group (30.97%, 83/268). Among patients with hypertension, the case group had significantly higher serum levels of TNFα, SP, NO, and ADM (t=25.464, 16.649, 19.772, and 13.835, P<0.05 for all) but a significantly lower serum level of CHE (t=-50257, P<0.05), as compared with the control group. ConclusionPatients with liver cirrhosis has a lower prevalence of hypertension than the general population, which may be related to increases in serum vasodilating factors such as SP, NO, and ADM.
【关键字】:肝硬化;高血压;肿瘤坏死因子α;胆碱酯酶类;P物质;一氧化氮;肾上腺髓质素
【Key words】:liver cirrhosis;hypertension; tumor necrosis factor-alpha; cholines terases; substance P; nitric oxide; adrenomedullin
【引证本文】:

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