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您现在的位置:首页 => 在线期刊 => 2014年 12期 => 肝胆胰疾病的内镜诊疗 =>经颈静脉肝内门体分流术与内镜治疗..
经颈静脉肝内门体分流术与内镜治疗预防肝硬化食管胃底静脉曲张再出血的Meta分析
Efficacy and safety of transjugular intrahepatic portosystemic shunt versus endoscopic therapy for prevention of variceal rebleeding in patients with cirrhosis: a meta-analysis
文章发布日期:2014年11月24日  来源:  作者:吴吉圆,张冬琴,张海月,等  点击次数:2204次  下载次数:486次

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【摘要】:目的比较经颈静脉肝内门体分流术(TIPS)与内镜治疗(ET)对降低肝硬化静脉曲张再出血的疗效和安全性。方法利用计算机在PubMed、Ovid、ScienceDirect、Embase、万方数据库、维普数据库中检索1970年1月1日 至2014年1月1日期间关于TIPS 和ET预防肝硬化食管胃静脉曲张再出血疗效方面的随机对照试验,选取符合条件的随机对照试验并对其进行质量评价。使用RevMan 5.2软件对静脉曲张再出血率、治疗后肝性脑病发生率、生存期及住院天数等指标进行Meta分析,并对其中的异质性、敏感性、偏倚作出初步判断。结果共纳入13项随机对照研究,包括 TIPS组475 例和ET组480 例患者。结果显示,与ET相比,TIPS有着更好地控制再出血率及病死率的疗效[相对危险度(RR)=0.48, 95%置信区间(CI): 0.39~0.58, P<0.001; RR=0.37, 95%CI :0.20~0.69, P=0.001)];但TIPS更易导致肝性脑病(RR=1.84, 95%CI:1.47~2.30, P<0.001)。二者术后总病死率、住院天数差异均无统计学意义[(RR=1.09, 95%CI:0.88~1.35, P=0.44; 加权均数差(WMD)=-0.44, 95%CI:-3.25~2.38, P=0.76)]。结论TIPS较之ET更易导致肝性脑病的发生,但在某些特殊情况下,TIPS仍是目前预防肝硬化静脉曲张再出血的第一选择。
【Abstract】:Objective To compare the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) versus endoscopic therapy (ET) in reducing recurrent variceal hemorrhage in patients with cirrhosis. Methods Data from randomized controlled trials (RCTs) ranging from January 1st, 1970 to January 1st, 2014 that compared the use of TIPS with ET for the prophylaxis of recurrent variceal bleeding in cirrhosis patients were retrieved from databases including PubMed, Ovid, ScienceDirect, Embase, Wanfang Data, and CNKI. The quality of eligible RCTs was assessed, and a meta-analysis was performed on the incidence of variceal rebleeding (VRB) and post-treatment encephalopathy, deaths due to rebleeding and other causes, and hospitalization days using the Cochrane Collaboration’s RevMan 5.2 software. Heterogeneity test and sensitivity analysis were performed, and publication biases were evaluated. Results Thirteen RCTs involving 475 cases of TIPS and 480 cases of ET were recruited in our study following the inclusion criteria. The meta-analysis showed that compared with the ET group, the TIPS group had a lower incidence of VRB [relative risk (RR) = 0.48, 95% confidence interval (CI): 0.39-0.58, P<0.001], reduced deaths due to rebleeding (RR = 0.37, 95%CI: 0.20-0.69, P = 0.001), but a higher incidence of post-treatment encephalopathy (RR = 1.84, 95%CI: 1.47-2.30, P<0.001). No significant differences were found in overall mortality and hospitalization days between the two groups (RR = 1.09, 95%CI: 0.88-1.35, P = 0.44; weighted mean difference = -0.44, 95%CI: -325-2.38, P = 0.76). Conclusions Compared with ET, TIPS increases the risk of hepatic encephalopathy. However, in some special cases, it remains the first choice of treatment to prevent variceal rebleeding.
【关键字】:肝硬化;食管和胃静脉曲张;门体分流术,经颈静脉肝内;Meta分析;治疗结果
【Key words】:liver cirrhosis; esophageal and gastric varices; portasystemic shunt, transjugular intrahepatic; Meta-analysis; treatment outcome
【引证本文】:

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