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您现在的位置:首页 => 在线期刊 => 2015年 2期 自身免疫性肝病 => 综述 =>慢性丙型肝炎铁代谢的失调机制
慢性丙型肝炎铁代谢的失调机制
Mechanism of iron metabolism disorder in patients with chronic hepatitis C
文章发布日期:2015年01月14日  来源:  作者:秦源, 郭永红,张颖,等  点击次数:2551次  下载次数:519次

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【摘要】:肝脏是人体储存铁离子的主要器官,因此铁离子代谢失常与慢性肝炎密切相关。目前,慢性丙型肝炎(CHC)中铁离子过载的机制并没有完全阐明。铁调素调控非常复杂,依赖于许多变量,包括不同阶段的肝脏炎症情况、转铁蛋白参与的铁离子循环以及胞内铁离子储存等,这些因素都与引起HCV相关肝脏疾病患者中铁离子浓度的变化有关。讨论了系统铁离子稳态的调控、CHC与铁离子失调的关系及诱发CHC铁离子过载的机制。认为深入认识铁离子稳态和相关信号通路之间的关系将促进HCV相关疾病的控制与治疗。
【Abstract】:Since the liver is the major iron storage organ in human body, iron metabolism disorder is closely related to chronic hepatitis. So far, the mechanisms underlying iron overload in chronic hepatitis C (CHC) have not been fully elucidated. Highly complex regulation of hepcidin relies on a number of variables, including hepatic inflammatory conditions of different stages, transferrin-bound iron circulation, and intracellular iron storage. All these factors are associated with variations in hepatic iron concentrations among patients with hepatitis C virus (HCV)-related chronic liver disease. This paper discusses the regulation of systemic iron homeostasis, the relationship between CHC and iron metabolism disorder, and the mechanism of inducing iron overload. In-depth understanding about iron homeostasis and the relationship between relevant signaling pathways will contribute to the control and therapy of HCV-related diseases.
【关键字】:肝炎,丙型,慢性;受体,转铁蛋白;铁蛋白质类;铁代谢障碍;综述
【Key words】:hepatiitis C, chronic; iron overload; receptors, transferrin; iron metabolism disorders; review
【引证本文】:

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