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成人肝母细胞瘤的诊治及研究进展
Research advances in diagnosis and treatment of adult hepatoblastoma
文章发布日期:2015年01月14日  来源:  作者:杨洁, 杜成友  点击次数:2299次  下载次数:522次

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【摘要】:成人肝母细胞瘤在临床上十分罕见,其发病机制尚不明确,目前对该疾病的总体认识不足,临床上极易误诊。介绍了肝母细胞瘤的发病机制、临床表现、影像学及病理学特点等内容,重点对成人肝母细胞瘤的治疗方式选择及最新的生物治疗研究进展作出了初步的阐述。通过对各种治疗方式的比较,认为目前治疗该疾病最佳的方案是以外科根治性切除手术为基础的综合治疗。但是由于该疾病恶性程度高,治疗经验匮乏,总体疗效仍不满意。最新的生物治疗靶点的相继报道可能为其治疗带来新的突破,但其临床疗效尚需检验,且成人肝母细胞瘤的发病机制是否与儿童一致也未有研究证实,指出还需进一步的临床研究加以证实和完善。
【Abstract】:Adult hepatoblastoma is extremely rare in clinical practice, and its pathogenesis is unknown. At present, there is a lack of understanding of this disease, and therefore clinical misdiagnosis is common. This review introduces the pathogenesis, clinical manifestations, and radiological and pathological characteristics of hepatoblastoma, focuses on the choice of treatment for adult hepatoblastoma, and explains briefly the latest research progress in biological therapy. Comparison of different treatments suggests that comprehensive treatment based on radical resection is still the best choice. However, the curative effect is poor since the disease is highly malignant and its treatment experience is insufficient. The newly reported target for biological therapy may represent a breakthrough for the treatment of the disease, but its clinical efficacy remains to be evaluated. The pathogenesis of the disease in adults and children has not been confirmed as the same, and the review indicates that further clinical research is still needed.
【关键字】:肝母细胞瘤;成年人;诊断;治疗;综述
【Key words】:hepatoblastoma; adult; diagnosis; therapy; review
【引证本文】:

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