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您现在的位置:首页 => 在线期刊 => 2015年 5期 胰腺疾病 => 胰腺疾病 =>C-反应蛋白在重症急性胰腺炎评估..
C-反应蛋白在重症急性胰腺炎评估与转归中的临床意义
Clinical significance of C-reactive protein for assessment and outcomes of severe acute pancreatitis
文章发布日期:2015年04月15日  来源:  作者:任丽楠,郭晓钟,李宏宇,等  点击次数:1436次  下载次数:290次

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【摘要】:目的了解重症急性胰腺炎(SAP)患者血清中CRP水平的变化情况,探讨CRP水平变化对于预测SAP患者的转归以及评估病情的价值和临床意义。方法选取2012年9月-2013年9月沈阳军区总医院收治的有完整病例资料的SAP患者52例,分别在入院时、入院后24、48、72、96、120和144 h抽取患者血液,检测患者血清中CRP的质量浓度,并观察其变化情况。结果SAP患者血清CRP质量浓度显著增高,且与其病情转归呈正相关。其中有42例(80.77%)SAP患者经过积极治疗,病情逐渐改善,其血清中CRP的质量浓度也逐渐减低(P<0.05);4例(7.69%)患者最终死亡,其血清中CRP质量浓度无明显下降,一直持续高值(P<0.05);其中6例(11.54%)患者病情先加重,而后经过积极治疗,患者转危为安,而血清中CRP的质量浓度也有同样呈现出先升高后回落的变化趋势(P<0.05)。结论SAP患者血清中CRP的含量随着病情的变化而发生相应的变化,其含量可以作为评估SAP病情和判断疾病转归的重要参考指标。
【Abstract】:ObjectiveTo study the change in serum CRP level in patients with severe acute pancreatitis (SAP), and to explore its clinical significance in predicting outcomes and assessing the severity of SAP. MethodsA retrospective analysis was performed on 52 SAP patients with complete case data and admitted to General Hospital of Shenyang Military Area Command from September 2013 to September 2014. Blood drawing was performed and serum CRP concentration was determined on admission and at 24, 48, 72, 96, 120, and 144 hours after admission. The pattern of its dynamic change was observed. ResultsSerum CRP level in SAP patients significantly increased, and had a positive correlation with clinical outcomes. Forty-two cases (80.77%) gradually recovered with aggressive treatment and the serum CRP levels were also slowly reduced (P<0.05). The serum CRP levels in four death cases (7.7%) had no significant decrease and was maintained at a high level (P<0.05). Six patients (11.53%) had aggravated conditions and recovered after aggressive treatment; meanwhile, the serum CRP levels first increased and then decreased (P<0.05). ConclusionFor SAP patients, serum CRP level fluctuates as their conditions change and can be considered as an important reference index for evaluating the severity and judging the outcomes of SAP.
【关键字】:胰腺炎,急性坏死性;C反应蛋白质
【Key words】:pancreatitis, acute necrotizing; C-reactive protein
【引证本文】:

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