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热休克蛋白70的表达与HBV相关肝细胞癌临床病理学特征的相关性分析
Analysis of association between HSP70 expression in tumor tissues and clinicopathological characteristics of HBV-related hepatocellular carcinoma
文章发布日期:2015年04月15日  来源:  作者:高加林,杨宗国,陈晓蓉,等  点击次数:1442次  下载次数:241次

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【摘要】:目的分析HBV相关肝细胞癌(HCC)肿瘤组织中热休克蛋白(HSP)70表达水平与HCC临床病理学特征的相关性。方法通过基因表达数据库(GEO)获取资料,对HSP70基因表达与HCC临床病理学特征进行统计学分析。分类变量采用频数(构成比)进行统计描述,统计分析采用χ2检验或Fisher确切概率法。HSP与HCC临床病理学特征相关性分析采用单因素及多因素Logistic回归分析,单因素分析显示P<0.10的变量纳入多因素分析。结果HSPA4L、HSPA6、HSPA13高表达患者HCC主瘤体>5 cm的比率明显高于低表达组(P值均<0.05);HSPA1A、HSPA6低表达组合并肝硬化的比率明显低于高表达组(P值均<0.05);HSPA5、HSPA13高表达组AFP>300 ng/ml的比率明显高于低表达组(P值均<0.01)。合并肝硬化和(或)主瘤体>5 cm的HCC患者生存率明显降低(P值均<0.05)。经Logistic多因素分析,HSPA4L高表达可促进HCC瘤体生长[OR=1.019,95%可信区间(95%CI):1.006~10032,P=0.003];HSPA1B高表达的HCC患者合并多发结节的风险较大(OR=1.002,95%CI:1.000~1.004,P=0.003)。结论HSPA4L及HSPA1B的表达与HCC临床病理学特征存在一定的相关性,可能为HCC治疗靶点及预后预测因子。
【Abstract】:ObjectiveTo investigate the relationship between heat shock protein 70 (HSP70) expression and clinicopathological characteristics of hepatitis virus B (HBV)-induced hepatocellular carcinoma (HCC). MethodsStatistical analysis was conducted to explore the association between the data of HSP70 obtained from the gene expression omnibus (GEO) and the clinicopathological characteristics of HCC. As for categorical data, frequency (proportion) was used to describe and chi-square test or Fisher′s exact test was applied to analyze. Univariate and multivariate logistic regression analyses were used to investigate the relationship between HSP expression and the clinicopathological characteristics of HCC. The variables with a P value less than 0.10 were included for subsequent multivariate analysis. Results1) The percentage of the HCC patients whose primary tumor sizes were more than 5 cm was significantly higher in the group with high expression of HSPA4L, HSPA6, and HSPA13 than in the group with low expression (P<0.05); in comparison with the group with high expression of HSPA1A and HSPA6, the group with low expression had a significantly lower percentage of patients accompanied by liver cirrhosis (P<0.05); there was a significantly higher percentage of patients with alpha-fetoprotein (AFP) levels more than 300 ng/ml in the group with high expression of HSPA5 and HSA13 compared with the group with low expression (P<0.01). 2) The survival rates of HCC patients with liver cirrhosis and/or primary tumor that was more than 5 cm significantly decreased (P<0.05). 3) Highly expressed HSPA4L might promote the growth of HCC (OR=1.019, 95% CI:1.006-10.032, P=0.003); the patients with high expression of HSPA1B might have a higher risk of developing multiple nodules (OR=1.002, 95%CI:1.000-1.004, P=0.003). ConclusionThe expression of HSPA4L and HSPA1B is, to some extent, associated with the clinicopathological characteristics of HCC, which might be a therapeutic target and prognostic predictor for HCC.
【关键字】:癌,肝细胞;HSP70热休克蛋白质类;肝炎病毒,乙型;病理学,临床
【Key words】:carcinoma, hepatocellular; HSP70 heat-shock proteins; hepatitis B virus; pathology, clinical
【引证本文】:

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