首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 5期 胰腺疾病 => 其他 =>钆塞酸二钠特异性增强磁共振成像评..
钆塞酸二钠特异性增强磁共振成像评估肝功能的临床价值
Value of Gd-EOB-DTPA-enhanced MRI in assessing liver function
文章发布日期:2015年04月15日  来源:  作者:王莉莉,雷军强,郭吉刚,等  点击次数:1835次  下载次数:335次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的探讨钆塞酸二钠(Gd-EOB-DTPA)特异性增强磁共振成像(MRI)评估一般人群肝功能的价值。方法筛选2013年6月-2014年9月在兰州大学第一医院接受15T MRI Gd-EOB-DTPA特异性增强扫描的患者,最终共纳入41例满足入组及排除标准的患者,获取其上腹部MRI平扫及Gd-EOB-DTPA增强扫描图像及部分临床信息。以脾脏作为肝脏信号强度的对照脏器,计算平扫及注射Gd-EOB-DTPA后10、20 min的肝-脾信号对比度(SI)、相对肝脏强化程度(RLE)。计量资料采用独立样本t检验或Mann-Whitney U检验,相关分析采用Spearman秩相关分析。结果注射造影剂10、20 min后的SI肝/脾与Child分级相关(P<0.05),且20 min SI肝/脾相关度更大(r=-0.526,P=0.003),而平扫SI肝/脾与Child分级无明显相关性(P>0.05);延迟20 min后的RLE也与Child分级相关(r=-0.362,P=0.049),而延迟10 min后的RLE与Child分级无明显相关性。平扫时肝硬化组和非肝硬化组患者之间SI肝/脾差异无统计学意义(P>0.05),而注射造影剂10、20 min后的SI肝/脾、RLE20 min差异有统计学意义(P值均<0.05);增强扫描20 min 后的SI肝/脾在ALT和TBil正常组与升高组之间差异都有统计学意义(P值均<0.05)。结论 Gd-EOB-DTPA 特异性增强扫描能够反映一般人群肝功能的变化,尤其是注射造影剂20 min后的 SI肝/脾对评估肝功能有重要价值。
【Abstract】:ObjectiveTo explore the value of magnetic resonance imaging (MRI) specifically enhanced with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) in assessing the liver function in general population. MethodsUpper abdominal MRI images and Gd-EOB-DTPA-enhanced images, as well as some clinical information, were collected from 41 cases meeting the inclusion and exclusion criteria. Taking the spleen as the control organ, liver-spleen signal intensity contrast (SIliver/spleen) and relative liver enhancement (RLE) were calculated at 10 min and 20 min after injecting Gd-EOB-DTPA. Differences were evaluated using the independent-samples t-test or Mann-Whitney U test. Corrections were analyzed via Spearman’s rank correlation. ResultsBoth SIliver/spleen at 10 min and 20 min after injection of contrast agent were correlated with Child classification (P<0.05). SIliver/spleen at 20 min had a greater correlation coefficient (r=-0.526) than that at 10 min. The SIliver/spleen with plain scan had no significant correlation with Child classification (P>0.05). RLE at 20 min, but not at 10 min, was correlated with Child classification (r=-0.362, P=0049). Between the cirrhotic and non-cirrhotic groups, SIliver/spleen showed no significant difference (P>0.05). However, SIliver/spleen at 10 min and 20 min, as well as RLE20 min, showed significant differences between the cirrhotic and non-cirrhotic groups (P<0.05). SIliver/spleen at 20 min also exhibited a significant difference between the elevated and normal ALT and TBil groups (both P<0.05). ConclusionGd-EOB-DTPA-enhanced MRI can monitor liver function changes, and SIliver/spleen at 20 min may have an important value in assessing the liver function in general population.
【关键字】:肝功能试验;磁共振成像;钆塞酸二钠;造影剂
【Key words】:liver function tests; magnetic resonance imaging; Gd-EOB-DTPA; contrast media
【引证本文】:

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号