首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 5期 胰腺疾病 => 其他 =>慢性肝病患者血清25-羟维生素D..
慢性肝病患者血清25-羟维生素D水平及临床意义
Levels and clinical significance of serum 25-hydroxy vitamin D in patients with chronic liver disease
文章发布日期:2015年04月15日  来源:  作者:杨伟民,辛桂杰,丁胜楠  点击次数:1683次  下载次数:310次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的探讨慢性肝病患者血清25-羟维生素D[25(OH)D]水平及其临床意义。方法收集2012年6月-2013年9月吉林大学第一医院肝胆胰内科153例慢性肝病住院患者的血清作为试验组,应用液相色谱串联质谱检测技术检测患者的25(OH)D水平,以同院体检中心300例健康人作对照组。试验组分为非肝硬化组、肝硬化组(Child-Pugh A、B、C级)及原发性胆汁性肝硬化(PBC)组,分析比较各组间的差异,计量资料采用t检验和方差分析,计数资料采用χ2检验,各变量间相关性采用Pearson直线相关分析。结果153例慢性肝病患者正常(≥30 ng/ml)、不足(20~30 ng/ml)、缺乏(10~20 ng/ml)及严重缺乏(<10 ng/ml)的比例分别为20.3%、22.9%、35.9%、20.9%。肝硬化组25(OH)D缺乏及严重缺乏的比例(41.7%、25.0%)明显多于非肝硬化组(275%、12.5%)及PBC组(23.5%、17.6%),差异均有统计学意义(χ2=6.261~18.474, P=0.001~0.012)。肝硬化组25(OH)D水平为(18.58±12.48)ng/ml,低于非肝硬化组(23.78±11.81)ng/ml及健康对照组(25.69±12.39)ng/ml,差异均有统计学意义(P值分别为0.029、0.001)。肝硬化组以Child-Pugh分级分组,C级25(OH)D水平明显低于A级,差异有统计学意义(P=0009)。结论慢性肝病患者血清25(OH)D水平普遍降低,其中肝硬化患者降低明显重于非肝硬化患者,尤其以Child-Pugh分级C级降低最为严重。
【Abstract】:ObjectiveTo investigate the levels and clinical significance of serum 25-hydroxy vitamin D[25(OH)D] in patients with chronic liver disease. MethodsA total of 153 hospitalized patients with chronic liver disease in the First Affiliated Hospital of Jilin University from June 2012 to September 2013 were enrolled in the study group. The levels of serum 25(OH)D were measured by liquid chromatography tandem mass spectrometry. The serum samples from 300 healthy volunteers who underwent physical examination in our hospital were used as controls. The study group was divided into three subgroups: non-cirrhosis, liver cirrhosis [Child-Pugh (CP) grades A, B, and C], and primary biliary cirrhosis. Comparison of continuous data between groups was made by t test and analysis of variance, and comparison of categorical data was made by chi-square test. Correlation between different variables was investigated by Pearson linear regression analysis. ResultsOf the 153 patients with chronic liver disease, the percentages of those who had vitamin D adequacy (≥30 ng/ml), insufficiency (20-30 ng/ml), deficiency (10-20 ng/ml), and severe deficiency (<10 ng/ml) were 20.3%, 22.9%, 35.9%, and 209%, respectively. The percentages of patients with vitamin D deficiency and severe deficiency were significantly higher in the cirrhosis subgroup than in the non-cirrhosis and primary biliary cirrhosis subgroups (41.7%, 25.0% vs 27.5%, 12.5% and 23.5%, 17.6%, respectively; χ2=6.261-18.474, P=0.001-0.012). The serum 25(OH)D levels in patients with cirrhosis were significantly lower compared with those in patients without cirrhosis and in controls (18.58±12.48 vs 23.78±11.81 and 25.69±12.39 ng/ml, P=0.029 and 0.001). CP class C cirrhotic patients had significantly lower serum levels of 25(OH)D compared with CP class A patients (P=0.009). ConclusionSerum 25(OH)D deficiency is common in patients with chronic liver disease. 25(OH)D levels in cirrhotic patients, especially in CP class C patients, are markedly lower than those in non-cirrhotic patients.
【关键字】:肝疾病;维生素D缺乏
【Key words】:liver diseases; vitamin D deficiency
【引证本文】:

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号