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您现在的位置:首页 => 在线期刊 => 2015年 5期 胰腺疾病 => 综述 =>胰性脑病脱髓鞘病变与髓鞘碱性蛋白..
胰性脑病脱髓鞘病变与髓鞘碱性蛋白的相关性
Analysis of relationship between demyelinating lesions and myelin basic protein in pancreatic encephalopathy
文章发布日期:2015年04月15日  来源:  作者:黄伯儒,赵海平,胡文秀  点击次数:1523次  下载次数:261次

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【摘要】:胰性脑病(PE)是重症急性胰腺炎(SAP)的严重并发症之一,早期诊断多依靠病史、临床症状及体征,病情发展快,合并多脏器功能不全,治疗不及时可发展多脏器功能衰竭,病死率高。现已知脱髓鞘是该病的重要病理特征,表现是脑灰质、白质的脂溶性脱髓鞘及出血、水肿等炎症改变。然而脱髓鞘病变的靶抗原是髓鞘碱性蛋白(MBP)。综述了PE中枢神经系统发生脱髓鞘病变时MBP水平变化,旨在为PE脱髓鞘病变、早期诊断及预后研究提供线索。
【Abstract】:Pancreatic encephalopathy (PE) is one of the severe complications of severe acute pancreatitis (SAP). Early diagnosis mostly depends on the history of disease as well as clinical symptoms and signs. PE progresses rapidly and is often complicated by multiple organ dysfunction, and it may finally develop into multiple organ failure with a high fatality rate if not treated in time. It is currently known that demyelination is one of the important pathological features of this disease, with fat-soluble demyelination of cerebral gray matter and white matter, as well as inflammatory changes such as hemorrhage and edema. The target antigen of demyelinating lesions, however, is myelin basic protein (MBP). This paper reviews the changes in MBP levels in the demyelinating lesions of the central nervous system among PE patients, with the purpose of providing clues for the early diagnosis and prognostic study of demyelinating lesions in PE.
【关键字】:胰性脑病;髓鞘溶解,中心性脑桥;髓磷脂碱性蛋白质类;综述
【Key words】:pancreatic encephalopathy; myelinolysis, central pontine; myelin basic proteins; review
【引证本文】:

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