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白细胞介素6与肝细胞癌相关性的Meta分析
Correlation between interleukin-6 and primary hepatocellular carcinoma: a meta-analysis
文章发布日期:2015年05月08日  来源:  作者:李霞,郝洪升  点击次数:1237次  下载次数:326次

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【摘要】:目的评价炎性细胞因子白细胞介素(IL)6与肝细胞癌的相关性。方法检索PubMed、ISI web of knowledge、中国生物医学文献数据库和中国期刊全文数据库,将定量检测肝癌患者血清或血浆中IL-6含量的病例对照试验纳入本研究,采用Meta分析法进行定量综合分析。结果纳入的25项研究分成3组分别进行Meta分析:肝癌和正常对照、肝癌和肝硬化以及肝癌和慢性肝炎。肝癌患者血清中IL-6水平显著高于健康人群[25篇,标准化均数差(SMD)为5.02 ,95%可信区间(95%CI):4.13~5.91, Z=11.05,P<0.000 1]、肝硬化患者(15篇,SMD=2.36, 95%CI: 1.54~3.19, Z=5.60, P<0.000 1)和肝炎患者(7篇,SMD=263, 95%CI: 1.24~4.03, Z=3.69, P=0.000 2)。结论炎症介质IL-6可能在肝癌发生发展中发挥重要作用。
【Abstract】:ObjectiveTo evaluate the correlation between interleukin (IL)6 and primary hepatocellular carcinoma (HCC). MethodsCase-control studies that included quantitative data on plasma or serum IL-6 levels of patients with HCC were identified from PubMed, ISI Web of Knowledge, CBM, and CNKI. A meta-analysis was performed to quantitatively and comprehensively analyze data. ResultsTwenty-five studies were included and the meta-analysis was conducted separately for 3 groups: HCC vs controls, HCC vs liver cirrhosis, and HCC vs hepatitis. The serum IL-6 levels of patients with HCC were significantly higher than those of healthy controls (25 studies, standardized mean difference (SMD) 5.02, 95% CI: 4.13-5.91, Z=11.05, P<0.000 1), patients with liver cirrhosis (15 studies, SMD=236, 95% CI: 1.54-3.19, Z=5.60, P<0.000 1), and patients with hepatitis (7 studies, SMD=2.63, 95% CI: 1.24-4.03, Z=369, P=0.000 2). ConclusionThe inflammatory mediator, IL-6, may play an important role in the development and progression of HCC.
【关键字】:癌,肝细胞;白细胞介素6;
【Key words】:carcinoma, hepatocellular; interleukin-6; Meta-analysis
【引证本文】:

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