首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 6期 原发性肝癌 => 综述 =>c-Met在肝细胞癌发生发展中的..
c-Met在肝细胞癌发生发展中的作用
Research progress in c-Met and hepatocellular carcinoma
文章发布日期:2015年05月08日  来源:  作者:王长青,国薇薇,刘政  点击次数:1705次  下载次数:428次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】: 摘要:c-Met在肝细胞癌的发生、发展中起着关键作用,可导致肿瘤细胞的增殖、存活、细胞骨架重组、分离扩散及血管生成等,同时还是评价预后的一个重要指标。c-Met在肝细胞癌中主要通过激活一系列信号通路发挥作用。近年来提出的小分子激酶抑制剂可阻止c-Met胞内羧基末端磷酸化,进而阻止信号转换器的募集及下游信号通路的传导,从而发挥抗肿瘤作用。基于对c-Met的了解及其在肝细胞癌中的致癌作用,指出了选择性c-Met抑制剂靶向治疗肝细胞癌的应用前景。
【Abstract】:c-Met plays a pivotal role in the development and progression of hepatocellular carcinoma (HCC), which can lead to proliferation, survival, cytoskeleton reorganization, separation and diffusion, and angiogenesis of tumor cells. Moreover, c-Met is an important prognostic factor for HCC. In HCC, c-Met acts as an activator of a series of signaling pathways, including PI3K/AKT/mTOR, ERK/MAPK, and Rac-Pak. In recent years, it has been reported that small-molecule kinase inhibitors can abolish phosphorylation at the intracellular carboxyl terminal of c-Met, and then inhibit the recruitment of signal convertors and downstream signaling pathways, which finally achieve anti-tumor activities. Based on the carcinogenic activity of c-Met in HCC, this paper points out that selective inhibitors of c-Met hold promise for targeted therapies for HCC.
【关键字】:癌,肝细胞;原癌基因蛋白质c-met;信号传导;综述
【Key words】:carcinoma, hepatocellular; proto-oncogene proteins c-met; signal transduction; review
【引证本文】:

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号