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Erlotinib治疗肝癌的临床研究进展
Clinical research progress in Erlotinib treatment for hepatocellular carcinoma
文章发布日期:2015年05月08日  来源:  作者:高帆,祁兴顺  点击次数:2329次  下载次数:466次

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【摘要】:Erlotinib可以选择性抑制表皮生长因子受体,以发挥抗肿瘤活性。总结了Erlotinib治疗肝癌的Ⅱ-Ⅲ临床试验结果。两项Ⅱ期临床试验提示Erlotinib单药治疗肝癌的疗效适中,两项来自美国的Ⅱ期临床试验发现Erlotinib联合Bevacizumab治疗肝癌可以达到较好的疗效,但其潜在增加静脉曲张出血的风险,而两项来自亚洲的Ⅱ期临床试验显示Erlotinib联合Bevacizumab治疗肝癌的疗效欠佳。最近,一项随机对照Ⅲ期试验并未能证实Erlotinib可以显著改善索拉非尼治疗肝癌的总体生存时间。未来的研究应根据临床及分子预后标志物去选择适合接受Erlotinib的肝癌患者,以更有效地鉴定Erlotinib适用人群。
【Abstract】:Erlotinib achieves antitumor activity by selective inhibition of the epidermal growth factor receptor. This paper summarizes the results of phase Ⅱ-Ⅲ clinical trials of erlotinib in the treatment of hepatocellular carcinoma (HCC). Two phase Ⅱ clinical trials demonstrated the modest antitumor activity of erlotinib alone in patients with HCC. Additionally, two phase Ⅱ clinical trials conducted in the USA showed the excellent efficacy of erlotinib combined with bevacizumab for HCC, but with an increased risk of variceal bleeding. By contrast, two phase Ⅱ clinical trials conducted in Asia showed the poor efficacy of erlotinib combined with bevacizumab for HCC. Recently, a randomized controlled phase Ⅲ trial failed to confirm any substantial improvement in overall survival time in HCC patients treated with sorafenib combined with erlotinib compared with sorafenib alone. Future studies should identify the candidates for erlotinib among patients with HCC based on the clinical and molecular prognostic biomarkers.
【关键字】:癌,肝细胞;临床试验;厄洛替尼;综述
【Key words】:carcinoma, hepatocellular; clinical trial; erlotinib; review
【引证本文】:

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