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磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路在肝胆恶性肿瘤发生发展中的作用
PI3K/Akt/mTOR signaling pathway and malignant hepatobiliary tumors
文章发布日期:2015年05月08日  来源:  作者:陈旭晓,陈拥军  点击次数:2337次  下载次数:462次

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【摘要】:磷脂酰肌醇-3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PI3K/Akt/mTOR)信号通路参与调节细胞代谢、生长、增殖、血管生成等多种重要生物过程,其高度激活的状态与多种恶性肿瘤的发生、发展相关。对PI3K/Akt/mTOR信号通路及mTOR蛋白进行了简单的介绍,并阐述了其在肝细胞癌、胆管细胞癌、胆管癌及胆囊癌发生发展中的作用机制,进一步简述了mTOR抑制剂在肝胆恶性肿瘤治疗中的作用。认为PI3K/Akt/mTOR信号通路为晚期肝胆恶性肿瘤提供了新的治疗靶点,新型mTOR抑制剂的不断研发将为晚期肝胆恶性肿瘤患者带来新的希望。
【Abstract】:Phosphoinositide-3 kinase/protein kinase-B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway is involved in many important biological processes such as cell metabolism, growth, proliferation, and angiogenesis. And its high-level activation is closely related to the development and progression of many malignant tumors. In this paper, mTOR and PI3K/Akt/mTOR signaling pathway are introduced, and their action mechanisms in the development and progression of hepatocellular carcinoma, cholangiocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma are expounded, and then the role of mTOR inhibitors in the treatment of malignant hepatobiliary tumors is briefly described. It is thought that the PI3K/Akt/mTOR signaling pathway provides new therapeutic targets for malignant hepatobiliary tumors in advanced stage and the constant development of new mTOR inhibitors provides some new hope for the patients with malignant hepatobiliary tumors in advanced stage.
【关键字】:肝肿瘤;胆道肿瘤;衔接蛋白质类,信号转导;综述
【Key words】:liver neoplasms; biliary tract neoplasms; adaptor proteins, signal transducing; review
【引证本文】:

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