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您现在的位置:首页 => 在线期刊 => 2015年 6期 原发性肝癌 => 综述 =>从调控肝再生探讨肝纤维化的防治
从调控肝再生探讨肝纤维化的防治
Prevention and treatment of liver fibrosis by regulating liver regeneration
文章发布日期:2015年05月08日  来源:  作者:李瀚旻  点击次数:2389次  下载次数:447次

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【摘要】:肝纤维化是肝再生紊乱的一种形式或状态。从调控肝再生的新视角探讨肝纤维化的防治,可以提出新的防治策略与方法:关注对抗性反向调节,更强调正向诱导;综合运用促进与抑制策略,改善肝损伤与肝再生,异常肝再生与正常肝再生失调;主张防治结合,防肝纤维化的发生或乱生,治肝纤维化的过亢进展。CCl4诱导的大鼠肝纤维化模型存在上皮-间质转型(EMT)/间质-上皮转型(MET)失衡的异常肝再生机制,地五养肝胶囊能延缓肝纤维化的病程进展,并减轻纤维化的程度,其作用机制之一是通过调节EMT/MET失衡(抑制EMT而促进MET)而改善肝再生过程。
【Abstract】: Liver fibrosis is regarded as a form or status of liver regeneration disorder. Therefore, from a new perspective of regulating liver regeneration, we put forward a new strategy for the prevention and treatment of liver fibrosis. This strategy not only focuses on confrontational reverse regulation, but also emphasizes positive induction. Moreover, this strategy applies an integrated method of promotion and inhibition, which improves liver injury and regeneration and corrects the abnormal liver regeneration and the normal liver regeneration disorder. Furthermore, this strategy also advocates the combination of prevention and treatment, which prevents the occurrence of liver fibrosis or a disorder of liver regeneration and treats the rapid progression of liver fibrosis. The imbalance between epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) is involved in the CCl4-induced liver fibrosis in rats. Diwu Yanggan capsules can delay the progression of liver fibrosis and attenuate the degree of fibrosis, which is associated with the regulation of liver regeneration by modulating the imbalance between EMT and MET (inhibiting EMT and/or promoting MET).
【关键字】:肝硬化;肝再生;中药疗法;综述
【Key words】:liver cirrhosis; liver regeneration; drug therapy(TCD); review
【引证本文】:

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