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西安地区青少年肥胖和非酒精性脂肪性肝病现状调查及相关危险因素分析
Prevalence and associated risk factors for obesity and nonalcoholic fatty liver disease in adolescents in Xi′an, Shaanxi province, China
文章发布日期:2015年08月11日  来源:  作者:赵鸿馨,闫蓉,牛春燕,等  点击次数:1317次  下载次数:276次

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【摘要】:目的 调查西安地区青少年肥胖和非酒精性脂肪性肝病(NAFLD)的流行现状及其相关危险因素,为青少年肥胖和NAFLD的预防及早期干预提供科学依据。 方法 收集2012年3-4月高考前于西安医学院第一附属医院体检的青少年,对其进行体格测量、肝功能检测和腹部B超检查。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验,进一步采用Logistic多因素回归分析NAFLD的危险因素。结果 共纳入4141例青少年,其中男2080例,女2061例,平均(18.62±0.66)岁。男生超重率和肥胖率均高于女生,差异均有统计学意义(χ2值分别为49.5、20.4,P值均<0.01);NAFLD总患病率为8.1%(335/4141),其中男生NAFLD患病率高于女生(13.4% vs 2.8%),差异具有统计学意义(χ2=156.4,P<0.01);NAFLD检出率由高至低依次为肥胖者、体质量超标者、BMI正常者,肥胖男生NAFLD检出率显著高于女生(71.6% vs 29.0%),差异具有统计学意义(χ2=56.5,P<0.01);男生及女生中NAFLD组BMI、体质量、ALT、AST均高于非NAFLD组,差异均有统计学意义(P值均<0.05)。Logistic回归分析显示,体质量和BMI可能是NAFLD的独立相关危险因素。结论 西安地区青少年肥胖、NAFLD发病情况不容乐观,对于肥胖青少年而言,合理的生活方式、控制体质量以及降低BMI是预防NAFLD的重要措施。
【Abstract】:Objective To provide a scientific basis for the prevention and early intervention of obesity and nonalcoholic fatty liver disease (NAFLD) in adolescents. Methods Anthropometric measurements, liver function test, and abdominal ultrasonography were performed in adolescents who received physical examination in our hospital from March to April, 2012. Between-group comparison of continuous data was made by t test, and between-group comparison of categorical data was made by χ2 test. The further multivariate analysis was performed by logistic regression analysis. Results A total of 4141 adolescents, including 2061 girls and 2080 boys, were enrolled in the study with an average age of 18.62±0.66 years. Boys had significantly higher overweight and obesity rates than girls (χ2=49.5, P<0.01; χ2=20.4, P<0.01). The overall incidence of NAFLD in subjects was 8.1% (335/4141), while the incidence of NAFLD in boys was significantly higher than that in girls (13.4% vs 2.8%, χ2=156.4, P<0.01). The detection rate of NAFLD was the highest in obese subjects, followed by subjects with high body mass index (BMI) and subjects with normal BMI. Moreover, obese boys had a significantly higher detection rate of NAFLD than obese girls (71.6% vs 29.0%, χ2=56.5, P<0.01). Among both boys and girls, BMI, body mass, alanine aminotransferase level, and aspartate aminotransferase level were significantly higher in the NAFLD group than in the non-NAFLD group (all P<0.05). Logistic regression analysis revealed that body mass and BMI were likely to be independent risk factors for NAFLD. Conclusion The prevalence of obesity and NAFLD in adolescents in Xi′an is not optimistic. For obese adolescents, healthy lifestyle, body mass control, and BMI reduction are important approaches for prevention of NAFLD.
【关键字】:脂肪肝;肥胖症;危险因素;青少年
【Key words】:fatty liver; obesity; risk factors; adolescent
【引证本文】:赵鸿馨, 闫蓉, 牛春燕, 等. 西安地区青少年肥胖和非酒精性脂肪性肝病现状调查及相关危险因素分析[J]. 临床肝胆病杂志, 2015, 31(8): 1248-1251.

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