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开滦集团职工胆囊结石临床流行病学调查
An epidemiological investigation of cholelithiasis in employees of Kailuan Corporation in Tangshan of Hebei Province, China
文章发布日期:2015年09月06日  来源:  作者:朱颖,吴治宇,马向明,等  点击次数:1991次  下载次数:417次

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【摘要】:目的探讨开滦研究人群胆囊结石的患病率及影响因素,为制订有效的防治方针提供依据。方法选择2006年6月-2007年10月参加开滦(集团)有限责任公司健康体检的101 510例在职及离退休职工,其中1133例胆囊结石资料缺失,最终纳入统计分析的有100 377例。进行统一问卷调查、血液生化及胆囊超声波监测。根据超声监测结果按有、无胆囊结石将观察对象分成两组,有胆囊结石组和无胆囊结石组。两组间比较采用t检验,率的比较采用χ2检验,并对胆囊结石的危险因素进行多因素Logistic回归分析。结果在100 377例观察对象中,男80 129例,女20 248例;年龄18~98岁,平均(51.89±12.66)岁。无胆囊结石98 109例(97.7%),有胆囊结石2268例(2.3%)。女性胆囊结石患病率高于男性(2.5% vs 2.2%),差异有统计学意义(χ2=4.60,P=0.033),且不论男女胆囊结石的患病率均随年龄的增长呈增高趋势。Logistic回归结果显示,性别、年龄、BMI、工种、空腹血糖(FPG)、高敏C反应蛋白(hs-CRP)、胆囊炎是胆囊结石的危险因素,其比值比分别为0.765[95%可信区间(95%CI):0.681~0.853]、1.439(95%CI:1.388~1.493)、1.40(95%CI:1.282~1.535)、0.821(95%CI:0.706~0.955)、1.234(95%CI:1.075~1.416)、1.080(95%CI:1.022~1.142)、12.519(95%CI:10.678~14.678)。 结论高龄、女性、肥胖、血糖、高hs-CRP、胆囊炎、不健康的生活方式是胆囊结石的危险因素。
【Abstract】:ObjectiveTo investigate the prevalence of cholelithiasis in the employees of Kailuan Corporation and to provide a reference for effective preventive measures. MethodsA total of 101 510 in-service or retired employees of Kailuan Corporation were recruited. All of them completed checkups organized by Kailuan Corporation from June 2006 to October 2007. The cholelithiasis examination data of 1133 employees were lost and the data of 100 377 employees were finally included in the statistical analysis. Questionnaire survey, blood biochemical examination, and ultrasound examination of the gallbladder were carried out. According to the ultrasound examination results, the subjects were divided into cholelithiasis group and non-cholelithiasis group. Comparison of the means between the two groups was made by t-test and comparison of the incidence rates between the two groups was made by chi-square test. The risk factors for cholelithiasis were assessed using multiple logistic regression analysis. ResultsThere were 80 129 males and 20 248 females in the 100 377 subjects. Their ages ranged from 18 to 98 years (mean, 51.89±12.66 years). There were 98 109 subjects without cholelithiasis and 2268 subjects (2.3%) with cholelithiasis. The females had a significantly higher incidence of cholelithiasis compared with the males (2.5% vs 2.2%, χ2=4.60, P=0.033). The incidence rate of cholelithiasis increased with age in both men and women. According to the result of logistic regression analysis, sex, age, body mass index, occupation, fasting plasma glucose, high-sensitivity C-reactive protein (hs-CRP), and cholecystitis were all risk factors for cholelithiasis and the odds ratios (95% confidence interval) of them were 0.765(0.687-0.853), 1.439(1.388-1.493), 1.403(1.282-1.535), 0.821(0.706-0.955), 1.234(1.075-1.416), 1.080(1.022-1.142), and 12.519(10.678-14.678), respectively. ConclusionPeople with advanced age, female sex, obesity, hyperglycemia, high hs-CRP, cholecystitis, or unhealthy lifestyle have high risk of cholelithiasis.
【关键字】:胆囊结石病;患病率;危险因素
【Key words】:cholecystolithiasis; prevalence; risk factors
【引证本文】:朱颖, 吴治宇, 马向明, 等. 开滦集团职工胆囊结石临床流行病学调查[J]. 临床肝胆病杂志, 2015, 31(10): 1621-1624.

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