首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 10期 胆汁淤积和胆道疾病 => 胆汁淤积和胆道疾病 =>吸烟与原发性胆汁性肝..
吸烟与原发性胆汁性肝硬化发病风险相关性的Meta分析
Association between smoking and risk of primary biliary cirrhosis: a meta-analysis
文章发布日期:2015年10月14日  来源:  作者:范鋆钰,孙凌云  点击次数:2272次  下载次数:414次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的从循证医学角度系统评价吸烟与原发性胆汁性肝硬化(PBC)发病的相关性。方法计算机检索 PubMed、Embsae、中国生物医学文献服务系统、中国知网、万方、维普数据库。中文检索词包括吸烟、香烟、原发性胆汁性肝硬化、危险因素、队列研究、病例对照研究,英文检索词包括smoking、cigarette、tobacco、risk factors、primary biliary cirrhosis、cohort studies、case-control studies。查找20多年来吸烟与PBC发病风险相关的病例对照研究,采用RevMan 5.2软件进行Meta分析,计算其比值比(OR)和95%可信区间(95%CI)并对发表偏倚进行漏斗图分析。结果纳入7个病例对照研究,共5459例,其中PBC患者2562例。Meta 分析结果显示,吸烟人群与不吸烟人群比较,其患PBC的风险增加(OR=1.49,95%CI:1.11~2.00,P=0.009)。按地域进行亚组分析,结果显示北美洲人群的OR为1.57,95%CI:1.20~2.04,P=0.000 8,吸烟组和非吸烟组PBC发病风险差异有统计学意义;但欧洲人群的OR为1.41,95%CI:0.73~2.73,P=0.31,吸烟组和非吸烟组PBC发病风险差异无统计学意义。结论本次研究证实吸烟会增加PBC的发病风险。由于各研究间存在异质性,上述结论仍需开展大样本量的规范化前瞻性研究进一步证实。
【Abstract】:ObjectiveTo systematically evaluate the association between smoking and the risk of primary biliary cirrhosis (PBC) from the perspective of evidence-based medicine. MethodsA literature search was performed in PubMed, EMBASE, CBM, CNKI, Wanfang Data, and VIP database to collect the case-control studies on the association between smoking and the risk of PBC published in the last two decades. Chinese search words were “吸烟”, “香烟”, “原发性胆汁性肝硬化”, “危险因素”, “队列研究”, and “病例对照研究”, and English search words were “smoking”, “cigarette”, “tobacco”, “risk factors”, “primary biliary cirrhosis”, “cohort studies”, and “case-control studies”. And then a meta-analysis was performed using Review Manager 5.2. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated, and the publication bias was analyzed by funnel plots. ResultsA total of 7 case-control studies involving 5459 subjects (2652 patients with PBC vs 2807 controls) were included in the meta-analysis. The analysis results showed that smokers had a significantly higher risk of PBC compared with non-smokers (OR=1.49, 95% CI: 1.11-2.00, P=0.009). The geographical subgroup analysis results showed that there was a significant difference in the risk of PBC between non-smokers and smokers in North America (OR=1.57, 95% CI: 1.20-2.04, P=0.0008). However, there was no significant difference in the risk of PBC between non-smokers and smokers in Europe (OR=1.41, 95% CI: 0.73-2.73, P=0.31). ConclusionSmoking can increase the risk of PBC. However, it needs to be confirmed in high-quality prospective studies with larger samples because of the heterogeneity of current included studies.
【关键字】:肝硬化,胆汁性;吸烟;Meta分析
【Key words】:liver cirrhosis, biliary; smoking; Meta-analysis
【引证本文】:范鋆钰, 孙凌云. 吸烟与原发性胆汁性肝硬化发病风险相关性的Meta分析[J]. 临床肝胆病杂志, 2015, 31(10): 1625-1629.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号