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启东地区2006-2014年高考生血清HBsAg携带状况分析
HBsAg seroprevalence in students for college entrance examination from 2006 to 2014 in Qidong of Jiangsu Province
文章发布日期:2015年10月14日  来源:  作者:倪正平,陈陶阳,沈蓉,等  点击次数:1730次  下载次数:329次

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【摘要】:目的了解启东青年一代血清HBsAg携带状况。方法随机选择启东市内三所中学2006-2014年连续9届高三学生(高考组),共15 534人,其中有部分学生在出生时接种过乙型肝炎疫苗。选择来自2007-2013年在本院体检的健康人群(成人组),共1208人,被确认未在出生时接种过乙型肝炎疫苗。两组对象以ELISA法进行血清HBsAg检测,观察其阳性率。组间比较采用χ2检验。结果高考组的HBsAg携带率分别为4.2%(75/1794)、4.3%(77/1797)、4.4%(82/1858)、4.3%(82/1903)、3.4%(56/1627)、2.6%(46/1768)、1.6%(29/1778)、1.6%(27/1642)和1.8%(24/1367),平均3.2%(498/15534),显著低于成人组的平均7.1%(86/1208)(χ2=59.986,P<0.001)。高考组男性HBsAg携带率(3.7%,266/7236)高于女性(2.8%,229/8298)(χ2=10.521,P=0.001);成人组男性HBsAg携带率(8.8%,66/750)也显著高于女性(4.4%,20/458)(χ2=8.452,P=0.004)。成人组男性的HBsAg携带率是高考组男性的2.4倍;成人组女性的HBsAg携带率是高考组女性的1.6倍。结论2006-2014年高考生的HBsAg携带率持续下降,至2014年已超前达到2010年世界卫生组织西太平洋区域将<5岁人群HBsAg携带率控制在2%以下的目标。
【Abstract】:ObjectiveTo investigate the HBsAg seroprevalence in the young generation in Qidong of Jiangsu Province, China. MethodsA total of 15 534 students for college entrance examination from 2006 to 2014 were randomly selected from three secondary schools in Qidong as student group. Some of them had hepatitis B vaccination at birth. A total of 1208 adults who had their routine checkups in our hospital from 2007 to 2013 were selected as adult group. It was confirmed that all of them did not have hepatitis B vaccination at birth. Serum HBsAg levels of the two groups were measured using enzyme-linked immunosorbent assay and the seroprevalence was analyzed. Comparison of data between the two groups was made by chi-square test. Results In the 9 years from 2007 to 2013, the seroprevalence rates of HBsAg in the student group were 4.2%(75/1794), 4.3%(77/1797), 4.4%(82/1858), 4.3%(82/1903), 3.4%(56/1627), 2.6%(46/1768), 1.6%(29/1778), 1.6%(27/1642), and 1.8%(24/1367), respectively. The mean HBsAg seroprevalence of the student group was 3.2%(498/15534), significantly lower compared with 7.1% (86/1208) of the adult group (χ2= 59.986, P<0.001). In both of the student group and the adult group, the males had a significantly higher HBsAg seroprevalence than the females (χ2=10.521, P=0.001; χ2=8.452, P=0.004) and the values were 3.7%(266/7236) vs 2.8%(229/8298) and 8.8%(66/750) vs 4.4%(20/458), respectively. Among male subjects, the HBsAg seroprevalence of the adult group was 2.4 times that of the student group; among female subjects, the HBsAg seroprevalence of the adult group was 1.6 times that of the student group. ConclusionIn the recent 9 years from 2006 to 2014, the HBsAg seroprevalence in students for college entrance examination declined continuously. The goal set by the World Health Organization Western Pacific Region in 2010 had been achieved ahead of the schedule that the HBsAg seroprevalence should be controlled below 2% in children aged less than 5.
【关键字】:肝炎表面抗原, 乙型;肝炎疫苗, 乙型;青少年
【Key words】:hepatitis B surface antigens;hepatitis B vaccines;adolescent
【引证本文】:倪正平, 陈陶阳, 沈蓉, 等. 启东地区2006-2014年高考生血清HBsAg携带状况分析[J]. 临床肝胆病杂志, 2015, 31(10): 1692-1694.

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