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合并HIV感染对慢性丙型肝炎患者抗病毒治疗的影响
Influence of concurrent HIV infection on antiviral therapy in patients with chronic hepatitis C
文章发布日期:2015年10月14日  来源:  作者:武志峰,张光文,杨萱  点击次数:1887次  下载次数:406次

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【摘要】:目的探讨合并人类免疫缺陷病毒(HIV)感染对慢性丙型肝炎(CHC)患者抗HCV疗效的影响。方法选取2013年1月-2014年10月在汝州市人民医院、郑州市第六人民医院治疗的合并HIV感染的丙型肝炎患者(合并HIV组)和单纯HCV感染患者(单纯HCV组)各28例,给予普通干扰素和利巴韦林联合抗HCV治疗,同时在治疗0、12、24、48周及治疗结束后24周检测HCV RNA载量、血常规,详细记录其他不良反应。计量资料组间比较采用t检验,计数资料采用χ2检验。结果2组患者给予抗病毒治疗后HCV RNA载量均逐渐下降,2组的持续病毒学应答(SVR)、治疗结束病毒学应答(ETVR)差异均有统计学意义(χ2值分别为6744、5.622,P值分别为0.013、0.024);在不良反应方面,2组患者白细胞水平均出现不同程度下降,在治疗12、24、48周时比较差异均有统计学意义(t值分别为3.422、4.443、2.949,P值均<0.01)。2组间血小板水平、消化道症状及类流感症状差异均无统计学意义(P值均>0.05)。结论合并HIV感染对CHC患者抗HCV的病毒学应答及不良反应均存在不同程度影响。
【Abstract】:ObjectiveTo investigate the influence of concurrent human immunodeficiency virus (HIV) infection on antiviral therapy for hepatitis C virus (HCV) in patients with chronic hepatitis C. MethodsTwenty-eight patients with hepatitis C and concurrent HIV infection (HCV/HIV group) and 28 patients with pure HCV infection (HCV group) treated in Ruzhou People′s Hospital and the Sixth People′s Hospital of Zhengzhou from 2013 to 2014 were selected and treated with common interferon combined with ribavirin as anti-HCV therapy. HCV RNA viral load and blood routine were measured at weeks 0, 12, 24, and 48 of therapy and 24 weeks after therapy, and other adverse effects were recorded in detail. The t-test was applied for comparison of continuous data between groups, and chi-square test was applied for comparison of categorical data between groups. ResultsHCV RNA viral load was gradually reduced after antiviral treatment in both groups, and the two groups showed significant differences in sustained virologic response and end-of-treatment virologic response (χ2=6744 vs 5.622, P=0.013 vs 0.024). As for adverse effects, the two groups showed decreases in leukocyte count, with significant differences between the two groups at weeks 12, 24, and 48 of therapy (t=3.422, 4.443, and 2.949, all P<0.01). The two groups showed no significant differences in platelet count, gastrointestinal symptoms, and flu-like symptoms (all P>0.05). ConclusionConcurrent HIV infection has varying degrees of influence on anti-HCV virologic response and adverse effects in patients with chronic hepatitis C.
【关键字】:肝炎,丙型,慢性;肝炎病毒属;HIV;治疗;危险因素
【Key words】:hepatitis C, chronic; hepacivirus; HIV; therapy; risk factors
【引证本文】:武志峰, 张光文, 杨萱. 合并HIV感染对慢性丙型肝炎患者抗病毒治疗的影响[J]. 临床肝胆病杂志, 2015, 31(11): 1837-1840.

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