首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 11期 丙型肝炎 => 病毒性肝炎 =>郴州地区门诊美沙酮吸毒人群HCV..
郴州地区门诊美沙酮吸毒人群HCV感染状况及基因型分布特征
Hepatitis C virus infection and genotype distribution among injecting drug users in methadone clinics in Chenzhou, China
文章发布日期:2015年10月14日  来源:  作者:骆珊,陈菲,张健,等  点击次数:2011次  下载次数:343次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的了解郴州地区美沙酮门诊静脉吸毒人群的HCV感染状况。方法采集2014年8-9月在郴州市美沙酮门诊中具有静脉吸毒史的181例患者血清,通过逆转录聚合酶链反应(RT-PCR)以及ELISA法分别检测HCV核酸和抗体,并通过测序确定HCV基因型。组间比较采用Mann-Whitney U检验。结果181例患者中HCV核酸或抗体阳性患者160例,阳性率为88.4%(160/181),其中抗体和核酸阳性(IgG+RNA+)134例(74%),抗体阳性核酸阴性(IgG+RNA-)19例(10.5%),抗体阴性核酸阳性(IgG-RNA+)7例(39%);HCV和 HBV共感染19例(10.5%)。HCV感染患者中IgG+RNA+组的ALT和AST水平明显高于IgG-RNA+组和IgG+RNA-组(P值均<0.01);HCV、HBV单感染患者ALT和AST水平与HBV 和HCV共感染患者比较,差异无统计学意义(P值均>005)。在133例HCV核酸阳性样本中,6a型81例(60.9%),3型36例(27.1%)。结论静脉吸毒人群具有高HCV感染率,HCV感染以6a型和3型为主,且HCV和 HBV共感染并不加重肝损伤。
【Abstract】:ObjectiveTo investigate the status of hepatitis C virus (HCV) infection among injecting drug users (IDUs) in Chenzhou, China. MethodsSerum samples from 181 IDUs who were treated in methadone clinics in Chenzhou from August to September, 2014 were collected. RT-PCR and ELISA were applied to detect HCV RNA and antibody, and sequencing was applied to determine the HCV genotype. Mann-Whitney U test was applied for comparison between groups. ResultsAmong these 181 IDUs, 160 were infected with HCV, with a positive rate of 88.4% (160/181); 134 patients had positive antibody and RNA results (IgG+RNA+: 74%), 19 patients had positive antibody and negative RNA results (IgG+RNA-: 10.5%), and 7 patients had negative antibody and positive RNA results (IgG-RNA+: 39%); 19 patients had co-infection with HCV and hepatitis B virus (HBV). The patients infected with HCV in IgG+RNA+ group had significantly higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels than those in IgG-RNA+ and IgG+RNA- groups (all P<0.01); ALT and AST levels did not differ significantly between patients with single infection with HCV or HBV and those with co-infection with HBV and HCV (all P>0.05). Among the 133 HCV RNA-positive samples, there were 81 samples of genotype 6a (60.9%) and 36 samples of genotype 3 (27.1%). ConclusionIDUs have a high HCV infection rate, with main genotypes of 6a and 3, and co-infection with HCV and HBV does not aggravate liver injury.
【关键字】:美沙酮;肝炎病毒属;感染;基因型
【Key words】:methadone; hepacivirus; infection; genotype
【引证本文】:骆珊, 陈菲, 张健, 等. 郴州地区门诊美沙酮吸毒人群HCV感染状况及基因型分布特征[J]. 临床肝胆病杂志, 2015, 31(11): 1841-1844.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号