首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2015年 12期 肝移植 => 病毒性肝炎 =>慢性乙型肝炎患者幽门螺杆菌感染与..
慢性乙型肝炎患者幽门螺杆菌感染与肝组织病理的关系
Association between Helicobacter pylori infection and stages of liver pathology in patients with chronic hepatitis B
文章发布日期:2015年11月20日  来源:  作者:温小凤,蒋忠胜,陈念,等  点击次数:1140次  下载次数:224次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的了解幽门螺杆菌(Hp)感染与慢性乙型肝炎(CHB)患者肝组织病理的关系。方法收集2008年2月-2014年12月在广西柳州市人民医院住院的CHB患者79例,所有患者均行肝活组织检查明确肝组织病理炎症分级(G)及纤维化分期(S),同时行14C尿素呼气试验(14C -UBT)检测患者是否存在Hp感染。根据14C结果将患者分为Hp阳性组(23例)和Hp阴性组(56例),分别比较2组患者肝组织炎症活动分级及纤维化分期。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验。结果 2组患者肝组织炎症活动分级及纤维化分期比较,差异均无统计学意义(t值分别为-1.622、-1.263,P值均>0.05);2组患者≥G2的比率比较差异无统计学意义(χ2=1.58,P>0.05),2组患者≥S2的比率比较差异亦无统计学意义(χ2=0.02,P>0.05)。结论Hp感染可能与CHB患者肝组织的炎症活动度及纤维化分期无关。
【Abstract】:ObjectiveTo investigate the association between Helicobacter pylori (Hp) infection and stages of liver pathology in patients with chronic hepatitis B (CHB). MethodsSeventy-nine patients who were hospitalized in the People’s Hospital of Liuzhou from February 2008 to December 2014 were selected, and liver biopsy was performed for all patients to determine the liver inflammation grade (G) and fibrosis stage (S). Meanwhile, 14C urea breath test (14C-UBT) was performed to detect Hp infection. The patients were divided into Hp-positive group and Hp-negative group based on the results of 14C-UBT, and liver inflammation grade and fibrosis stage were compared between the two groups. The t-test was applied for comparison of continuous data between the two groups, and χ2 test was applied for comparison of categorical data between the two groups. ResultsThere were no differences in liver inflammation grade or fibrosis stage between Hp-positive group and Hp-negative group (t=-1.622 and -1.263, respectively; both P>0.05); there was no difference in the proportion of patients ≥G2 between the two groups (χ2=1.58; P>0.05); there was no difference in the proportion of patients ≥S2 between the two groups (χ2=0.02; P>0.05). ConclusionHp infection may not be associated with liver inflammation grade or fibrosis stage in patients with CHB.
【关键字】:肝炎,乙型,慢性;螺杆菌,幽门;病理学,临床
【Key words】: hepatitis B, chronic; helicobacter pylori; clinical pathology
【引证本文】:温小凤, 蒋忠胜, 陈念, 等. 慢性乙型肝炎患者幽门螺杆菌感染与肝组织病理的关系[J]. 临床肝胆病杂志, 2015, 31(12): 2051-2053.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号