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肝细胞核因子4α在肝脏疾病发生发展过程中的作用
The role of hepatocyte nuclear factor 4 alpha in development and progression of liver diseases
文章发布日期:2016年02月06日  来源:  作者:杨金连,汪艳  点击次数:1443次  下载次数:282次

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【摘要】:肝细胞核因子(HNF)4α属于细胞核受体超家族成员,在分化成熟的肝细胞中高表达。HNF4α在转录水平上调控肝脏特异基因的表达,促进肝细胞的发育和分化,参与肝细胞极性的建立和维持,增强肝脏的合成、代谢以及解毒功能。HNF4α可通过抑制肝星状细胞的活化、逆转上皮间质细胞转化、抑制肝癌细胞增殖、侵袭和转移等机制,参与肝纤维化、肝硬化、肝细胞癌等疾病的发生和变化过程。阐述了HNF4α的生物学功能,对其参与多种主要肝脏疾病信号通路机制的研究进展进行了分析总结,旨在为进一步发掘这一潜在的肝脏疾病靶向治疗途径提供参考。
【Abstract】:Hepatocyte nuclear factor 4 alpha (HNF4α), a member of the nuclear receptor superfamily, has a high expression level in mature hepatocytes. HNF4α can regulate hepatocyte-specific gene expression at a transcriptional level, promote hepatocyte development and differentiation, participate in establishment and maintenance of hepatocyte polarity, and enhance the synthetic, metabolic, and detoxifying functions of the liver. Through inhibiting the activation of hepatic stellate cells, reversing epithelial-mesenchymal transition, and inhibiting the proliferation, invasion, and metastasis of hepatoma cells, HNF4α may be involved in the development and progression of various liver diseases including liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. This paper elaborates on the biological functions of HNF4α, and summarizes and analyzes the research advances in the mechanisms of action of HNF4α in the pathological process of liver diseases, in order to provide references for further investigation of the potential targeted therapies for liver diseases.
【关键字】:肝疾病;肝细胞核因子4;综述
【Key words】:liver diseases; hepatocyte nuclear factor 4; review
【引证本文】:杨金连,汪艳. 肝细胞核因子4α在肝脏疾病发生发展中的作用[J]. 临床肝胆病杂志, 2016, 32(2): 397-403.

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