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磁共振弹性成像在肝纤维化无创诊断中的应用
Application of magnetic resonance elastography as a non-invasive technique for diagnosis of liver fibrosis
文章发布日期:2016年02月06日  来源:  作者:杨明磊,姚定康  点击次数:1202次  下载次数:230次

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【摘要】:目前以活组织病理检查作为肝纤维化诊断分级的金标准,然而其具有明显的局限性,无创检测方法成为临床的需求,磁共振弹性成像(MRE)是目前研究的热点。回顾了MRE在相关领域的临床进展,研究显示其在肝纤维化的诊断和分级中具有很高的灵敏度、特异度,受试者工作特征曲线下面积可达0.95以上,具有极高的诊断价值。与血清学和其他影像学诊断方式相比,MRE可更加明确地进行肝纤维化分期,具有良好的重复性和客观性,可在除血色病患者的其他患者中广泛应用,尤其在肥胖和腹水患者的诊断中具有独特优势,弥补了其他方法的不足。认为MRE可能成为评价肝纤维化,尤其是高级别纤维化最具价值的诊断方法。
【Abstract】:At present, liver biopsy is the gold standard for the diagnosis and grading of liver fibrosis, but its limitations have been widely acknowledged. The non-invasive detection methods are needed in clinical practice, and at present, magnetic resonance elastography (MRE) is a hot research topic. This article reviews the advances in the clinical application of MRE in related fields, and studies have shown that MRE has a high diagnostic value due to its high sensitivity and specificity in the diagnosis and grading of liver fibrosis and an area under the receiver operating characteristic curve as high as 0.95. Compared with serological and other imaging diagnostic methods, MRE can determine fibrosis stage more accurately and has good reproducibility and objectivity. MRE can be widely applied in all patients except those with hemochromatosis, with special advantages in the diagnosis for patients with obesity and ascites, and can make up for the disadvantages of other methods. This article points out that MRE may become the best non-invasive method for the assessment of liver fibrosis, especially advanced fibrosis.
【关键字】:肝硬化; 弹性成像技术; 诊断; 综述
【Key words】:liver cirrhosis; elasticity imaging techniques; diagnosis; review
【引证本文】:杨明磊, 姚定康. 磁共振弹性成像在肝纤维化无创诊断中的应用[J]. 临床肝胆病杂志, 2016, 32(3): 588-592.

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