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健康体检成人 FibroScan 检测肝脏硬度值与年龄、性别的相关性
Correlation of liver stiffness measured by FibroScan with sex and age in healthy adults undergoing physical examination
文章发布日期:2016年03月11日  来源:  作者:赵崇山,何文艳,王宁方,等  点击次数:2087次  下载次数:267次

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【摘要】:目的界定正常人群肝脏硬度值参考范围及探讨年龄、性别对肝脏硬度值的影响。方法收集2012年10月1日-2014年10月31日于中国石油天然气集团公司中心医院进行体检的健康人群1794例,经FibroScan进行肝脏硬度值(LSM)检测。因LSM的分布不服从正态分布,采用Wilcoxon秩和检验比较不同性别组间LSM;采用Kruskal-Wallis 检验比较不同年龄段间LSM,采用Spearman秩相关分析LSM与年龄的相关性;采用单侧百分位法制订性别、年龄段的正常参考值范围。结果其中1590例LSM测定成功有效,有效率为88.63%,107例因肝功能异常被剔除,经分析发现男性受试者LSM高于女性受试者,男女间比较LSM差异有统计学意义(Z=-4.980,P<0.001);不同年龄段间LSM差异亦有统计学意义(χ2=16.983,P=0.001),并证实年龄与LSM呈正相关(r=0.087,P=0.001),参考范围(P90)估计:成人≤7.1 kPa,女性≤7.0 kPa,男性≤7.2 kPa;按年龄划分20~29岁≤6.8 kPa,30~44岁≤6.7 kPa,45~59岁≤7.8 kPa,60~74岁≤8.8 kPa。结论LSM受年龄、性别影响,在体检人群中应用时需根据年龄、性别参考相应的医学参考值范围。
【Abstract】:ObjectiveTo determine the reference range of liver stiffness in healthy population, and to investigate the influence of age and sex on liver stiffness. MethodsA total of 1794 healthy subjects who underwent physical examination in China National Petroleum Corporation Central Hospital from October 1, 2012 to October 31, 2014 were enrolled, and FibroScan was used to perform liver stiffness measurement (LSM). Since LSM value was not normally distributed, the Wilcoxon rank sum test was used to compare LSM value between male and female patients, the Kruskal-Wallis test was used to compare LSM value between different age groups, and the Spearman's rank correlation analysis was used to analyze the correlation between LSM value and age. The one-sided percentile method was used to determine the range of normal reference values in male and female subjects or in different age groups. ResultsLSM was successfully performed in 1590 patients, and the rate of successful measurement was 88.63%. A total of 107 patients were excluded due to abnormal liver enzymes. The analysis showed that LSM value showed a significant difference between male and female subjects (Z=-4.980, P<0.001), as well as between different age groups (χ2=16.983, P=0.001). Age was positively correlated with LSM value (r=0.087, P=0.001). The reference range was estimated to be ≤7.1 kPa in adults, ≤7.0 kPa in females, and ≤7.2 kPa in males. From the perspective of age, the reference range was estimated to be ≤6.8 kPa in persons aged 20-29 years, ≤6.7 kPa in persons aged 30-44 years, ≤7.8 kPa in persons aged 45-59 years, and ≤8.8 kPa in persons aged 60-74 years. ConclusionLiver stiffness value is influenced by sex and age. Sex and age should be taken into account while performing liver stiffness measurement in healthy subjects.
【关键字】:弹性成像技术;肝脏硬度值;性别因素;年龄分布;参考值
【Key words】:elasticity imaging technigues; liver stiffness measurement; sex factors; age distribution; reference values
【引证本文】:赵崇山,何文艳,王宁方,等. 健康体检成人 FibroScan 检测肝脏硬度值与年龄、性别的相关性[J]. 临床肝胆病杂志, 2016, 32(4): 724-727.

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