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非高密度脂蛋白胆固醇水平与新疆维吾尔族绝经后女性非酒精性脂肪性肝病的关系
Association between non-high-density lipoprotein cholesterol and nonalcoholic fatty liver disease in postmenopausal Uyghur women in Xinjiang, China
文章发布日期:2016年05月06日  来源:  作者:买拉木古丽,加那尔古丽·夏坎,蔡雯,等  点击次数:1317次  下载次数:283次

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【摘要】:目的探讨非高密度脂蛋白胆固醇(non-HDL-C)水平与新疆维吾尔族绝经后女性非酒精性脂肪性肝病(NAFLD)的关系。方法选取2014年7月-2015年8月在新疆乌鲁木齐市第一附属医院和新疆喀什地区第一人民医院体检中心健康体检的1271例绝经后维吾尔族女性为研究对象,以是否患有NAFLD将其分为NAFLD组(682例)和对照组(589例),详细测量并记录研究对象人口学资料并测定肝脏酶学指标、糖脂代谢、尿酸及non-HDL-C等指标。计量资料组间比较采用t检验,计数资料组间比较采用χ2检验,采用非条件Logistic回归分析影响绝经后女性发生NAFLD的危险因素。结果NAFLD组血清尿酸、空腹血糖、甘油三酯(TG)、糖化血红蛋白、ALT、AST、腰围、臀围、BMI、腰臀比、收缩压、舒张压、non-HDL-C水平均高于对照组,而HDL-C与脂联素水平较对照组低,差异均有统计学意义(P值均<005)。non-HDL-C<3.58 mmol/L组血糖、总胆固醇、TG、AST、ALT、低密度脂蛋白胆固醇水平显著低于non-HDL-C≥3.58 mmol/L组,差异均有统计学意义(P值均<005)。多因素Logistic回归分析显示,non-HDL-C、血清尿酸和BMI是绝经期女性NAFLD的危险因素。结论除了向心性肥胖、高甘油三酯血症、高尿酸血症是NAFLD的危险因素外,non-HDL-C水平亦是绝经后女性非酒精性脂肪肝的主要危险因素。
【Abstract】:Abstract:ObjectiveTo investigate the association between non-high-density lipoprotein cholesterol (non-HDL-C) and nonalcoholic fatty liver disease (NAFLD) in postmenopausal Uyghur women in Xinjiang, China. MethodsA total of 1271 postmenopausal Uyghur women who underwent physical examination in the physical examination centers of hospitals in Urumqi and Kashi, Xinjiang, were enrolled as study subjects, and according to the presence or absence of NAFLD, they were divided into NAFLD group (682 women) and control group (589 women). Demographic data were recorded in detail, and the hepatic enzyme parameters, parameters for glucose and lipid metabolism, and parameters including uric acid and non-HDL-C were measured. The t-test was used for comparison of continuous data between groups, the chi-square test was used for comparison of categorical data between groups, and non-conditional logistic regression analysis was used to determine the risk factors for NAFLD in postmenopausal women. ResultsCompared with the control group, the NAFLD group had significantly higher uric acid, fasting blood glucose, triglyceride (TG), glycosylated hemoglobin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), waist circumference, hip circumference, body mass index, waist-hip ratio, systolic pressure, diastolic pressure, and non-HDL-C level (all P<0.05), and a significantly lower HDL-C level (P<0.05). Compared with the group with a non-HDL-C level of ≥3.58 mmol/L, the group with a non-HDL-C level of <3.58 mmol/L had significantly lower levels of blood glucose, total cholesterol, TG, AST, ALT, and low-density lipoprotein cholesterol. The multivariate logistic regression analysis showed that non-HDL-C, serum uric acid, and BMI were risk factors for NAFLD in postmenopausal women. ConclusionNon-HDL-C, along with central obesity, hypertriglyceridemia, and hyperuricemia, is a major risk factor for NAFLD in postmenopausal women.
【关键字】:脂肪肝;胆固醇,HDL;绝经期;危险因素;维吾尔族
【Key words】:fatty liver; cholesterol, HDL; menopause; risk factors; URGUR NATIONALITY
【引证本文】:买拉木古丽, 加那尔古丽·夏坎, 蔡雯, 等. 非高密度脂蛋白胆固醇水平与新疆维吾尔族绝经后女性非酒精性脂肪性肝病的相关性[J]. 临床肝胆病杂志, 2016, 32(6): 1155-1159.

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