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HBeAg阴性慢性乙型肝炎获得HBsAg清除与血清白细胞介素17水平的关系
Association between serum level of interleukin-17 and HBsAg clearance in patients with HBeAg-negative chronic hepatitis B
文章发布日期:2016年06月08日  来源:  作者:曹振环,柳雅立,马丽娜,等  点击次数:1213次  下载次数:257次

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【摘要】:目的探讨聚乙二醇干扰素(PEG-IFN)治疗HBeAg阴性慢性乙型肝炎(CHB)发生HBsAg清除与血清白细胞介素(IL)17水平的关系。方法选择2012年1月-2015年1月于北京佑安医院就诊的HBeAg阴性CHB患者13例,经PEG-IFN治疗24周,其中6例获得HBsAg清除(R组),7例未获得HBsAg清除(NR组)。用Luminex技术检测患者基线、治疗12周和24周血清IL-17水平。同时检测10例健康人和6例急性乙型肝炎(AHB)患者发病时的血清IL-17水平。计量资料两组间比较采用t检验,多组间比较采用方差分析,进一步两两比较采用SNK-q检验;计数资料组间比较采用χ2检验。结果AHB组基线血清IL-17水平最高,其次是CHB组,健康对照组最低,3组间比较差异有统计学意义(P<0.05)。CHB患者经PEG-IFN治疗24周后,IL-17水平较基线明显下降(P=0044)。R组基线血清IL-17水平高于NR组,而且在PEG-IFN治疗后明显下降;而NR组IL-17升高或降低不明显。结论PEG-IFN治疗HBeAg阴性CHB患者,IL-17基线高水平和治疗过程中明显降低可能有利于HBsAg清除。
【Abstract】:ObjectiveTo investigate the association between HBsAg clearance and serum level of interleukin-17 (IL-17) in HBeAg-negative chronic hepatitis B (CHB) patients treated by pegylated interferon (PEG-IFN). MethodsA total of 13 HBeAg-negative CHB patients who visited Beijing YouAn Hospital from January 2012 to January 2015 were enrolled. After the 24-week treatment with PEG-IFN, 6 achieved HBsAg clearance (R group) and 7 did not achieve HBsAg clearance (NR group). The Luminex technology was used to measure the serum level of IL-17 at baseline and weeks 12 and 24 of treatment. Ten healthy controls and 6 patients with acute hepatitis B (AHB) were enrolled and serum level of IL-17 was measured. An analysis of variance was used for comparison of continuous data between multiple groups, and the SNK-q test was used for further pairwise comparison; the t-test was used for comparison of continuous data between any two groups; the chi-square test was used for comparison of categorical data between groups. ResultsThe AHB group had the highest serum level of IL-17 at baseline, followed by the CHB group and healthy control group, and the serum level of IL-17 at baseline showed significant differences between the three groups (P<0.05). After the PEG-IFN treatment for 24 weeks, HBeAg-negative CHB patients showed a significant reduction in serum level of IL-17 (P=0.044). R group had a significantly higher serum level of IL-17 than NR group and showed a significant reduction in the serum level of IL-17 after PEG-IFN treatment, while NR group showed no significant increase or reduction in the serum level of IL-17. ConclusionIn the PEG-IFN treatment for HBeAg-negative CHB patients, a high serum level of IL-17 at baseline and a significant reduction in serum level of IL-17 helps with HBsAg clearance.
【关键字】:肝炎, 乙型, 慢性; 肝炎e抗原, 乙型; 肝炎表面抗原, 乙型; 白细胞介素17
【Key words】:hepatitis B, chronic; hepatitis B e antigens; hepatitis B surface antigens; interleukin-17
【引证本文】:曹振环, 柳雅立, 马丽娜, 等. HBeAg阴性慢性乙型肝炎获得HBsAg清除与血清白细胞介素17水平的关系[J]. 临床肝胆病杂志, 2016, 32(7): 1292-1295.

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