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肝衰竭的病情评估及预后判断
Disease assessment and prognosis of liver failure
文章发布日期:2016年08月08日  来源:  作者:张 静, 周新民  点击次数:1313次  下载次数:318次

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【摘要】:肝衰竭是一类病死率高且严重威胁人类健康的肝脏疾病,肝移植是降低病死率的有效治疗手段。由于供体缺乏、异体排斥等问题导致肝移植的应用受到限制。早期准确的评估系统有助于判断病情,优化治疗策略。目前应用较多的预后评估系统包括英国爱丁堡大学皇家医学院标准、MELD、整合MELD模型、Child-Pugh评分、慢性肝衰竭-序贯性器官衰竭评分(CLIF-SOFA)、CLIF-C ACLFs及D-MELD等,不同的评分系统有各自的优缺点。其中,MELD是最常用的评分系统,D-MELD评分系统是可用于等待肝移植患者的最具创新性的评分标准。主要阐述了肝衰竭各种评分系统的特点及其临床预测价值。
【Abstract】:Liver failure has a high fatality rate and greatly threatens human health. Liver transplantation can effectively reduce the fatality rate. However, the problems such as donor shortage and allograft rejection limit the wide application of liver transplantation. An accurate early assessment helps to evaluate patients′ condition and optimize therapeutic strategies. At present, commonly used systems for prognostic evaluation include the King′s College Hospital, MELD, integrated MELD, Child-Pugh score, CLIF-SOFA, CLIF-C ACLFS, and D-MELD, and each system has its own advantages and disadvantages. Among these systems, the MELD scoring system is the most commonly used one, and the D-MELD scoring system is the most innovative one, which can be used for patients on the waiting list for liver transplantation. This article elaborates on the characteristics and predictive value of each scoring system in clinical practice.
【关键字】:肝功能衰竭; 肝移植; 预后; 评分系统
【Key words】:liver failure; liver transplantation; prognosis; scoring system
【引证本文】:张静, 周新民. 肝衰竭的病情评估及预后判断[J]. 临床肝胆病杂志, 2016, 32(9): 1673-1677.

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