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HBeAg阳性慢性HBV感染者血清HBsAg、PTA与吲哚菁绿15分钟滞留率的相关性分析
Correlation between HBsAg, prothrombin time activity, and indocyanine green retention rate at 15 minutes in patients with HBeAg-positive chronic HBV infection
文章发布日期:2016年09月28日  来源:  作者:范文海,赵正斌,陈青锋,等  点击次数:1584次  下载次数:262次

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【摘要】:目的分析HBeAg阳性HBV感染者的HBsAg、PTA和吲哚菁绿15 min滞留率(ICG R15),并研究三者之间的相关性。方法选取2015年12月-2016年4月兰州大学第一医院收治的HBeAg阳性HBV感染者92例,分为慢性乙型肝炎组(n=24)、肝硬化代偿组(n=38)和肝硬化失代偿组(n=30)。对所有患者进行血清HBsAg定量、PTA及肝脏储备功能ICG R15检测。计数资料组间比较采用χ2检验,计量资料多组间比较采用方差分析,相关性比较采用Pearson相关分析法。结果三组患者血清HBsAg定量比较,差异有统计学意义[(3.82±0.43) log10IU/ml vs (2.88±0.36) log10IU/ml vs (2.60±0.27) log10IU/ml,F=25.19,P<0001];三组患者的ICG R15比较差异有统计学意义(7.51±3.10)% vs (9.57±8.18)% vs (24.13±14.28)%,F=24.00,P=0001];三组患者的PTA比较,差异亦有统计学意义[(81.00±17.62)% vs (83.08±9.64)% vs (62.32±16.90)%,F=13.42,P=0.009]。相关分析显示三组间PTA与ICG R15均呈负相关(r值分别为-0.948、-0.602、-0.735,P值均<0.01);肝硬化代偿组和失代偿组患者HBsAg与PTA呈正相关(r值分别为0.410、0.473,P值均<0.05),与ICG R15呈负相关(r值分别为-0.427、-0768,P值均<0.01)。结论在HBeAg阳性条件下HBsAg、PTA与ICG R15有相关性,一定程度上可以反映慢性HBV感染者的肝脏储备功能。
【Abstract】:ObjectiveTo investigate the correlation between HBsAg, prothrombin time activity (PTA), and indocyanine green retention rate at 15 minutes (ICG R15) in patients with HBeAg-positive chronic HBV infection. MethodsA total of 92 patients with HBeAg-positive chronic HBV infection who were admitted to The First Hospital of Lanzhou University from December 2015 to April 2016 were enrolled and divided into chronic hepatitis B (CHB) group (24 patients), compensated liver cirrhosis group (38 patients), and decompensated liver cirrhosis group (30 patients). Serum HBsAg quantitation, PTA test, and liver reserve function test (ICG R15) were performed for all patients. The chi-square test was used for comparison of categorical data between groups, an analysis of variance was used for comparison of continuous data between multiple groups, and a Pearson correlation analysis was also performed. ResultsThere were significant differences between the three groups in serum HBsAg quantitation (3.82±0.43 log10IU/ml vs 2.88±0.36 log10IU/ml vs 2.60±0.27 log10IU/ml, F=25.19, P<0.001), ICG R15 (7.51%±3.10% vs 9.57%±8.18% vs 24.13%±14.28%, F=24.00, P=0.001), and PTA (8100%±1762% vs 83.08%±9.64% vs 62.32%±16.90%, F=13.42, P=0.009). The correlation analysis showed that PTA was negatively correlated with ICG R15 in all three groups (r=-0.948, -0.602, and -0.735, all P<0.01). In the compensated liver cirrhosis group and decompensated liver cirrhosis group, HBsAg was positively correlated with PTA (r=0.410 and 0.473, both P<0.05) and negatively correlated with ICG R15 (r=-0.427 and -0.768, P<0.01). ConclusionIn HBeAg positive patients, there are certain correlations between HBsAg, PTA, and ICG R15, which, to a certain degree, reflects the liver reserve function in patients with chronic HBV infection.
【关键字】:肝炎,乙型,慢性; 肝炎e抗原,乙型; 肝炎表面抗原,乙型; 凝血酶原; 吲哚花青绿
【Key words】:hepatitis B,chronic; hepatitis B e antigens; hepatitis B surface antigens; prothrombin; indocyanine green
【引证本文】:范文海, 赵正斌, 陈青锋, 等. HBeAg阳性慢性HBV感染者血清HBsAg、PTA与吲哚菁绿15分钟滞留率的相关性分析[J]. 临床肝胆病杂志, 2016, 32(11): 2099-2102.

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