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特利加压素治疗失代偿期肝硬化并发低钠血症的机制和处理原则
Mechanisms of hyponatremia in patients with decompensated liver cirrhosis treated with terlipressin and related treatment principles
文章发布日期:2016年09月28日  来源:  作者:游佳,江家骥  点击次数:1311次  下载次数:343次

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【摘要】:食管胃静脉曲张出血和肝肾综合征是失代偿期肝硬化患者门静脉高压的常见并发症,特利加压素可以收缩内脏血管、降低门静脉压力、增加肾脏灌注,是一线治疗药物。近年来陆续报道了部分患者在接受特利加压素治疗期间发生了低钠血症。由于肝硬化患者本身容易发生低钠血症,使用特利加压素可能不利于患者血钠水平的管理。总结了特利加压素治疗期间低钠血症的发生率以及危险因素,主要介绍了特利加压素治疗失代偿期肝硬化患者期间低钠血症的发生机制以及低钠血症的处理原则,若能控制低钠血症的发生,特利加压素则是治疗门静脉高压并发症的有效药物。
【Abstract】:Esophagogastric variceal bleeding and hepatorenal syndrome are common complications in patients with decompensated liver cirrhosis and portal hypertension. Terlipressin can lead to the constriction of visceral vessels, reduce portal venous pressure, and increase renal perfusion and is the first-line drug. In recent years, it has been reported that some patients experienced hyponatremia during the treatment with terlipressin. Since patients with liver cirrhosis tend to develop hyponatremia, the application of terlipressin may have an adverse effect on the management of serum sodium level in such patients. This article summarizes the incidence rate of hyponatremia during terlipressin treatment and related risk factors and introduces the pathogenesis of hyponatremia during terlipressin treatment in patients with decompensated liver cirrhosis and the treatment principles for hyponatremia. If the occurrence of hyponatremia can be controlled, terlipressin may be an effective drug for the treatment of portal hypertension.
【关键字】:肝硬化; 低钠血症; 赖氨酸加压素; 综述
【Key words】:liver cirrhosis; hyponatremia; lysine vasopressin; review
【引证本文】:游佳, 江家骥. 特利加压素治疗失代偿期肝硬化并发低钠血症的机制和处理原则[J]. 临床肝胆病杂志, 2016, 32(11): 2191-2194.

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