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半胱氨酰白三烯受体1在胰腺癌组织中的表达及临床意义
Expression of cysteinyl leukotriene receptor-1 in pancreatic cancer tissue and its clinical significance
文章发布日期:2016年12月07日  来源:  作者:孟艳,朱莹,张亚庆,等  点击次数:1688次  下载次数:320次

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【摘要】:目的探讨半胱氨酰白三烯受体(CysLTR)1在胰腺癌组织中的表达及其与临床特征和预后的关系。方法选取2015年1月-10月葫芦岛中心医院收治的病理确诊为胰腺癌的患者42例,收集癌组织及癌旁组织,采用real-time PCR检测组织CysLTR-1 mRNA相对表达量,并对患者随访1年。计量资料两组间比较采用t检验;多组间比较采用方差分析,进一步两两比较采用LSD-t检验。胰腺癌患者预后的影响因素采用多因素logistic回归分析。结果癌组织中CysLTR-1 mRNA相对表达量高于癌旁组织,差异有统计学意义(0.037 1±0.020 5 vs 0.016 8±0.011 4,t=6.58,P<0.001);CysLTR-1 mRNA相对表达量与患者的TNM分期(t=2.731,P=0.009)、分化程度(F=10.537,P<0.001)和淋巴结转移相关(t=3.408,P=0.002)。随访期内死亡17例,存活25例;死亡患者CysLTR-1 mRNA相对表达量高于存活患者(0.045 6±0.021 7 vs 0.031 3±0.019 8),差异有统计学意义(t=2.21,P=0.03)。logistic回归分析显示,TNM分期[比值比(OR)=6.92,95%可信区间(95%CI):1.30~36.82,P=0.02]、分化程度(OR=5.71,95%CI:1.44~22.62,P=0.01)以及淋巴结转移(OR=9.62,95%CI:2.23~41.46,P<0.001)是影响胰腺癌预后的危险因素;控制患者年龄、性别、TNM分期、肿瘤分化程度、肿瘤发生部位及淋巴结转移等因素后,CysLTR-1 mRNA表达量仍是影响患者预后的危险因素(OR=1.11,95%CI:1.07~1.15,P=0.03)。结论CysLTR-1参与胰腺癌的发生、发展过程,可作为判断胰腺癌预后的分子标志物。
【Abstract】:ObjectiveTo investigate the expression of cysteinyl leukotriene receptor-1 (CysLTR-1) in pancreatic cancer tissue and its association with clinical features and prognosis. MethodsA total of 42 patients with pathologically confirmed pancreatic cancer who were admitted to Central Hospital of Huludao from January to October, 2015 were enrolled, and cancer and adjacent tissues were collected. Real-time PCR was used to measure the relative mRNA expression of CysLTR-1 in these tissues, and the patients were followed up for 1 year. The t-test was used for comparison of continuous data between groups; an analysis of variance was used for comparison between multiple groups, and the least significant difference t-test was used for comparison between any two groups. The multivariate logistic regression analysis was used to determine influential factors for the prognosis of patients with pancreatic cancer. ResultsThe cancer tissues had significantly higher relative mRNA expression of CysLTR-1 than adjacent tissues (0.037 1±0.020 5 vs 0.016 8±0.011 4, t=6.58, P<0.001). The relative mRNA expression of CysLTR-1 was associated with TNM stage (t=2.731, P=0.009), degree of tumor differentiation (F=10.537, P<0.001), and lymph node metastasis (t=3.408, P=0.002). During the 1-year follow-up, 17 patients died and 25 survived; the patients who died had significantly higher relative mRNA expression of CysLTR-1 than those who survived (0.045 6±0.021 7 vs 0.031 3±0.019 8, t=2.21, P=0.03). The logistic regression analysis showed that TNM stage (OR=6.92, 95%CI: 1.30-36.82, P=0.02), degree of tumor differentiation (OR=5.71, 95%CI: 1.44-22.62, P=0.01), and lymph node metastasis (OR=9.62, 95%CI: 2.23-41.46, P<0.001) were prognostic factors for pancreatic cancer. After adjustment for age, sex, TNM stage, degree of tumor differentiation, tumor location, and lymph node metastasis, the mRNA expression of CysLTR-1 was still a prognostic factor for patients with pancreatic cancer (OR=1.11, 95%CI: 1.07-1.15, P=0.03). Conclusion CysLTR-1 is involved in the development and progression of pancreatic cancer and can be used as a new molecular marker for prognostic evaluation in patients with pancreatic cancer.
【关键字】:胰腺肿瘤;受体,白三烯;肿瘤标记,生物学
【Key words】:pancreatic neoplasms; receptors, leukotriene; tumor markers, biological
【引证本文】:孟艳, 朱莹, 张亚庆, 等. 半胱氨酰白三烯受体1在胰腺癌组织中的表达及临床意义[J]. 临床肝胆病杂志, 2017, 33(1): 133-136.

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