首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2017年 4期肝胆胰疾病的微创治疗 => 综述 =>HBV复制再激活的研..
HBV复制再激活的研究进展
Research advances in hepatitis B virus reactivation
文章发布日期:2017年03月07日  来源:  作者:李梦苑,叶传涛,张颖,等  点击次数:1780次  下载次数:364次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:在非活动性或已治愈的HBV感染者中,当机体免疫稳态被打破时,可能发生以肝脏炎症反应和HBV DNA水平增高为表现的HBV再激活(HBVr)现象,进而引起不同程度的肝功能异常、肝衰竭甚至死亡。对于HBVr的筛查、免疫抑制方案的危险分级以及患者个体情况等方面的系统性管理是亟待解决的问题,在免疫抑制治疗及化疗前筛查HBV血清学标志,评估患者HBVr的发生风险,制订合适的个体化预防性抗病毒治疗方案尤为关键。彻底清除肝细胞内cccDNA是预防HBVr发生的根本。从病因、发病机制、诊断、预防及治疗等方面详细介绍了HBVr的相关研究进展。
【Abstract】:In non-active or cured patients with hepatitis B virus (HBV) infection, when the body′s immune homeostasis is broken, HBV reactivation may occur, with the manifestations of liver inflammation and increased HBV DNA level, and lead to varying degrees of abnormal liver function, liver failure, and even death. Systematic management from the aspects of the screening of HBV reactivation, risk stratification of immunosuppression regimens, and patient's individual information needs to be solved urgently. It is very important to perform the screening of HBV serological markers before immunosuppressive therapy and chemotherapy, evaluate the risk of HBV reactivation, and develop individualized prophylactic antiviral therapy. Complete removal of covalently closed circular DNA in hepatocytes is essential for preventing HBV reactivation. This article summarizes related research advances in HBV reactivation from the aspects of its etiology, pathogenesis, diagnosis, prevention, and treatment.
【关键字】:肝炎病毒, 乙型; 病毒激活; 综述
【Key words】:hepatitis B virus; virus activation; reviews
【引证本文】:李梦苑, 叶传涛, 张颖, 等. HBV复制再激活研究进展[J]. 临床肝胆病杂志, 2017, 33(4): 751-756.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号